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PMID: 19684591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Change detection by thalamic reticular neurons.

Nature neuroscience ·Vol. 12 ·No. 9 ·2009-09-00 ·Pages 1165-70

Yu XJ, Xu XX, He S, He J

Abstract

The thalamic reticular nucleus (TRN) is thought to function in the attentional searchlight. We analyzed the detection of deviant acoustic stimuli by TRN neurons and the consequences of deviance detection on the TRN target, the medial geniculate body (MGB) of the rat. TRN neurons responded more strongly to pure-tone stimuli presented as deviant stimuli (low appearance probability) than those presented as standard stimuli (high probability) (deviance-detection index = 0.321). MGB neurons also showed deviance detection in this procedure, albeit to a smaller extent (deviance-detection index = 0.154). TRN neuron deviance detection either enhanced (14 neurons) or suppressed (27 neurons) MGB neuronal responses to a probe stimulus. Both effects were neutralized by inactivation of the auditory TRN. Deviance modulation effects were cross-modal. Deviance detection probably causes TRN neurons to transiently deactivate surrounding TRN neurons in response to a fresh stimulus, altering auditory thalamus responses and inducing attention shift.

MeSH Terms
Acoustic Stimulation Action Potentials Analysis of Variance Animals Auditory Perception/physiology Female Geniculate Bodies/physiology Male Microelectrodes Neurons/physiology Neuropsychological Tests Photic Stimulation Probability Rats Rats, Wistar Signal Detection, Psychological/physiology Thalamic Nuclei/physiology Visual Perception/physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yu Xiong-Jie
CAS-Hong Kong Joint Research Laboratory for Visuo-Auditory Integration, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xu Xin-Xiu
He Shigang
He Jufang
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1546-1726
DOI
10.1038/nn.2373
Published
2009-09-00
Epub
2009-00-16
Pages
1165-70
Language
English
Region
United States
NLM ID
9809671
Subset
IM
External Links
PubMed source DOI: 10.1038/nn.2373 View journal details
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