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PMID: 19686278 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Diversity in VIM-2-encoding class 1 integrons and occasional blaSHV2a carriage in isolates of a persistent, multidrug-resistant Pseudomonas aeruginosa clone from Tunis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases ·Vol. 16 ·No. 2 ·2010-02-00 ·页码 189-93

Hammami S, Gautier V, Ghozzi R, Da Costa A, Ben-Redjeb S, Arlet G

Abstract

From 2002 to 2006, 35 of 73 multidrug-resistant Pseudomonas aeruginosa isolates from different wards at Charles Nicolle hospital of Tunis were positive for class B carbapenemase (using the imipenem-EDTA test), owing to a bla(VIM-2) gene cassette in a class 1 integron. Twenty-three isolates additionally produced the extended-spectrum beta-lactamase SHV2a. DNA sequences immediately surrounding bla(SHV2a) shared extensive identity with a Klebsiella pneumoniae plasmid sequence. Despite belonging to the same chromosomal type, as shown by pulsed-field gel electrophoresis (PFGE), the VIM-2 producing P. aeruginosa isolates prevalent at Charles Nicolle hospital displayed a diversity of VIM-2-carrying integrons.

MeSH 主题词

Adult Aged Anti-Bacterial Agents/pharmacology Bacterial Proteins/genetics Child, Preschool DNA, Bacterial/chemistry,genetics Drug Resistance, Multiple, Bacterial Electrophoresis, Gel, Pulsed-Field Female Genetic Variation Hospitals Humans Infant Integrons Klebsiella pneumoniae/genetics Male Middle Aged Molecular Sequence Data Pseudomonas Infections/microbiology Pseudomonas aeruginosa/drug effects,enzymology,genetics,isolation & purification Sequence Analysis, DNA Sequence Homology Tunisia Young Adult beta-Lactamases/genetics

化学物质

Anti-Bacterial Agents Bacterial Proteins DNA, Bacterial beta-lactamase bla(vim-2) beta-Lactamases

作者与单位

共 6 位作者，点击展开单位 / ORCID

Hammami S

Laboratoire de Recherche Résistance aux Antimicrobiens, LR99ES09, Département de Microbiologie, Faculté de Médecine de Tunis, Tunis, Tunisia.

Gautier V

Ghozzi R

Da Costa A

Ben-Redjeb S

Arlet G

Article Info

Journal

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

Abbr.

Clin Microbiol Infect

ISSN

1469-0691

DOI

10.1111/j.1469-0691.2009.03023.x

Published

2010-02-00

电子出版

2009-00-17

页码

189-93

Language

English

Country/Region

England

NLM ID

9516420

数据资源

GENBANK

AM774408, AM988778, AM988779, FM897214, FM955585

External Links

PubMed source DOI: 10.1111/j.1469-0691.2009.03023.x View journal details

Analysis Services

Diversity in VIM-2-encoding class 1 integrons and occasional blaSHV2a carriage in isolates of a persistent, multidrug-resistant Pseudomonas aeruginosa clone from Tunis.

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