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PMID: 1968708 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.

American journal of human genetics ·Vol. 46 ·No. 3 ·1990-03-00 ·Pages 613-23

Schurr TG, Ballinger SW, Gan YY, Hodge JA, Merriwether DA, Lawrence DN, Knowler WC, Weiss KM, Wallace DC

Abstract

The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations.

MeSH Terms
Asia Asians/genetics Base Sequence DNA Probes DNA, Mitochondrial/genetics Gene Frequency Humans Indians, Central American/genetics Indians, North American/genetics Indians, South American/genetics Molecular Sequence Data Mutation Phylogeny Polymerase Chain Reaction Polymorphism, Restriction Fragment Length
Chemicals
DNA Probes DNA, Mitochondrial
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Schurr T G
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA.
Ballinger S W
Gan Y Y
Hodge J A
Merriwether D A
Lawrence D N
Knowler W C
Weiss K M
Wallace D C
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1990-03-00
Pages
613-23
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1683611
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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