The era of genomic epidemiology.
The recent revolution in genomics is already having a profound impact on the practice of epidemiology. The purpose of this commentary is to demonstrate how genomics and epidemiology will continue to rely heavily on each other, now and in the future, by illustrating a number of interaction points between these 2 disciplines: (1) the use of genomics to estimate disease heritability; (2) the impact of genomics on analytical study design; (3) how genome-wide data can be employed to effectively overcome residual population stratification arising from selection bias; (4) the importance of genomics as a tool in epidemiological investigation; (5) the importance of epidemiology in the collection of adequately phenotyped samples for genomics studies, and (6) for unraveling the clinical and therapeutic relevance of genetic variants once they are discovered.
18 references, click to expand
-
Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection.Lancet. 2003 May 24;361(9371):1779-85 PMID: 12781537
-
Complement factor H polymorphism in age-related macular degeneration.Science. 2005 Apr 15;308(5720):385-9 PMID: 15761122
-
A common LRRK2 mutation in idiopathic Parkinson's disease.Lancet. 2005 Jan 29-Feb 4;365(9457):415-6 PMID: 15680457
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.Nat Genet. 2008 Aug;40(8):955-62 PMID: 18587394
-
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.Nat Genet. 2007 Aug;39(8):977-83 PMID: 17603485
-
Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.Nat Med. 1995 Feb;1(2):135-7 PMID: 7585009
-
SARS molecular epidemiology: a Chinese fairy tale of controlling an emerging zoonotic disease in the genomics era.Philos Trans R Soc Lond B Biol Sci. 2007 Jun 29;362(1482):1063-81 PMID: 17327210
-
Genome-wide association studies in neurological disorders.Lancet Neurol. 2008 Nov;7(11):1067-72 PMID: 18940696
-
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.BMC Med Genet. 2007 Sep 19;8 Suppl 1:S15 PMID: 17903297
-
Characterization of a novel coronavirus associated with severe acute respiratory syndrome.Science. 2003 May 30;300(5624):1394-9 PMID: 12730500
-
Genetics of sporadic amyotrophic lateral sclerosis.Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R233-42 PMID: 17911166
-
Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway.PLoS One. 2008 Jan 16;3(1):e1449 PMID: 18197259
-
The evolution of epidemic influenza.Nat Rev Genet. 2007 Mar;8(3):196-205 PMID: 17262054
-
A genetic link between type 2 diabetes and prostate cancer.Diabetologia. 2008 Oct;51(10):1757-60 PMID: 18696045
-
The emergence of epidemiology in the genomics age.Int J Epidemiol. 2004 Oct;33(5):936-44 PMID: 15319400
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.Neuron. 2004 Nov 18;44(4):595-600 PMID: 15541308
-
The Genome sequence of the SARS-associated coronavirus.Science. 2003 May 30;300(5624):1399-404 PMID: 12730501
-
Environment and cancer: who are susceptible?Science. 1997 Nov 7;278(5340):1068-73 PMID: 9353182
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
