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PMID: 19701197 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Neurod1 is essential for the survival and maturation of adult-born neurons.

Nature neuroscience ·Vol. 12 ·No. 9 ·2009-09-00 ·Pages 1090-2

Gao Z, Ure K, Ables JL, Lagace DC, Nave KA, Goebbels S, Eisch AJ, Hsieh J

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

MeSH Terms

Adult Stem Cells/physiology Animals Astrocytes/physiology Basic Helix-Loop-Helix Transcription Factors/genetics,metabolism Cell Differentiation/physiology Cell Survival/physiology Cells, Cultured Hippocampus/physiology Mice Mice, Knockout Mice, Transgenic Neurogenesis/physiology Neurons/physiology Olfactory Bulb/physiology Time Factors

Chemicals

Basic Helix-Loop-Helix Transcription Factors Neurod1 protein, mouse

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Gao Zhengliang

Department of Molecular Biology and Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Ure Kerstin

Ables Jessica L

Lagace Diane C

Nave Klaus-Armin

Goebbels Sandra

Eisch Amelia J

Hsieh Jenny

References (12)

12 references, click to expand

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Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1546-1726

DOI

10.1038/nn.2385

Published

2009-09-00

Epub

2009-00-23

Pages

1090-2

Language

English

Region

United States

NLM ID

9809671

PMCID

PMC3365543

Subset

Grants

NIDA NIH HHS · K02 DA023555 · United States

NIDA NIH HHS · R01 DA016765 · United States

NIDA NIH HHS · R21 DA023701 · United States

Corrections

CommentIn

PMID: 19710645

External Links

PubMed source DOI: 10.1038/nn.2385 PMC Full Text View journal details

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Neurod1 is essential for the survival and maturation of adult-born neurons.

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