Home LiteratureArticle Details
PMID: 19706590 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation.

Pediatrics ·Vol. 124 ·No. 3 ·2009-09-00 ·Pages e450-8

Bose C, Van Marter LJ, Laughon M, O'Shea TM, Allred EN, Karna P, Ehrenkranz RA, Boggess K, Leviton A, Extremely Low Gestational Age Newborn Study Investigators

Abstract

Improvement in survival of extremely premature infants over the past several decades has resulted in an increase in the number of infants with chronic lung disease (CLD). Historical neonatal exposures associated with CLD now less frequently precede the disease. There is now increasing interest in exposures and events before delivery that predict CLD. The objective of this study was to identify current prenatal predictors of CLD. We collected data about prenatal, placental, and neonatal characteristics of 1241 newborns who were delivered before completion of the 28th week of gestation. Associations between prenatal factors, microbiologic and histologic characteristics of the placenta, and selected neonatal characteristics and CLD risk were first evaluated in univariate analyses. Subsequent multivariate analyses investigated the contribution of prenatal factors, particularly fetal growth restriction (FGR), to CLD risk. Among the prenatal factors, birth weight z scores, used as a marker of FGR, provided the most information about CLD risk. Indicators of placental inflammation and infection were not associated with increased risk of CLD. Within nearly all strata of prenatal, placental, and neonatal variables, growth-restricted infants were at increased CLD risk, compared with infants who were not growth-restricted. FGR was the only maternal or prenatal characteristic that was highly predictive of CLD after adjustment for other risk factors. FGR is independently associated with the risk of CLD. Thus, factors that control fetal somatic growth may have a significant impact on vulnerability to lung injury and in this way increase CLD risk.

MeSH Terms
Chronic Disease Female Fetal Growth Retardation Gestational Age Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases/epidemiology,etiology Lung Diseases/epidemiology,etiology Male Risk Factors
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Bose Carl
Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [email protected]
Van Marter Linda J
Laughon Matthew
O'Shea T Michael
Allred Elizabeth N
Karna Padmani
Ehrenkranz Richard A
Boggess Kim
Leviton Alan
Extremely Low Gestational Age Newborn Study Investigators
Investigators
15 investigators, click to expand
Dammann Olaf
Shah Bhavesh L
Martin Camilia
Insoft Robert
Kuban Karl
Bednarek Francis
Fiascone John
Engelke Stephen C
Poortenga Mariel
Beaumont Ed
Paneth Nigel
Schreiber Michael D
Batton Daniel
Pavlov Greg
Hirtz Deborah
References (41)
41 references, click to expand
  1. Neonatal cranial ultrasound lesions and developmental delays at 2 years of age among extremely low gestational age children.
    Pediatrics. 2008 Sep;122(3):e662-9 PMID: 18762501
  2. Impact of improved survival of very low-birth-weight infants on incidence and severity of bronchopulmonary dysplasia.
    Biol Neonate. 2004;86(2):124-30 PMID: 15192303
  3. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia.
    N Engl J Med. 1967 Feb 16;276(7):357-68 PMID: 5334613
  4. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants.
    Pediatr Res. 2004 Jun;55(6):1009-17 PMID: 15155869
  5. Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung.
    Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L86-95 PMID: 18487357
  6. Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response.
    Hum Pathol. 2001 Jun;32(6):623-9 PMID: 11431717
  7. Placental growth factor and vascular endothelial growth factor receptor-2 in human lung development.
    Pediatrics. 2008 Aug;122(2):340-6 PMID: 18676552
  8. Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era.
    Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F128-33 PMID: 15724036
  9. New birthweight and head circumference centiles for gestational ages 24 to 42 weeks.
    Early Hum Dev. 1987 Jan;15(1):45-52 PMID: 3816638
  10. Histological characteristics of singleton placentas delivered before the 28th week of gestation.
    Pathology. 2008 Jun;40(4):372-6 PMID: 18446627
  11. Frequency and risk factors in bronchopulmonary dysplasia in a cohort of very low birth weight infants.
    Early Hum Dev. 1999 Apr;54(3):245-58 PMID: 10321791
  12. Separation of individual-level and cluster-level covariate effects in regression analysis of correlated data.
    Stat Med. 2003 Aug 30;22(16):2591-602 PMID: 12898546
  13. Increased morbidity in severe early intrauterine growth restriction.
    J Perinatol. 2004 Jul;24(7):435-40 PMID: 15116139
  14. The NICHD neonatal research network: changes in practice and outcomes during the first 15 years.
    Semin Perinatol. 2003 Aug;27(4):281-7 PMID: 14510318
  15. Increased risk of bronchopulmonary dysplasia and increased mortality in very preterm infants being small for gestational age.
    Arch Gynecol Obstet. 2003 Nov;269(1):40-4 PMID: 12682849
  16. Patterns of respiratory disease during the first 2 postnatal weeks in extremely premature infants.
    Pediatrics. 2009 Apr;123(4):1124-31 PMID: 19336371
  17. Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates.
    J Perinat Med. 2005;33(5):428-34 PMID: 16238538
  18. Trends in mortality and cerebral palsy in a geographically based cohort of very low birth weight neonates born between 1982 to 1994.
    Pediatrics. 1998 Apr;101(4 Pt 1):642-7 PMID: 9521949
  19. Colonization of second-trimester placenta parenchyma.
    Am J Obstet Gynecol. 2008 Jul;199(1):52.e1-52.e10 PMID: 18313635
  20. Intrauterine growth restriction increases morbidity and mortality among premature neonates.
    Am J Obstet Gynecol. 2004 Aug;191(2):481-7 PMID: 15343225
  21. Necrotizing enterocolitis: treatment based on staging criteria.
    Pediatr Clin North Am. 1986 Feb;33(1):179-201 PMID: 3081865
  22. Conventional birth weight standards obscure fetal growth restriction in preterm infants.
    Arch Dis Child Fetal Neonatal Ed. 2007 May;92(3):F189-92 PMID: 16547077
  23. Trends in mortality and morbidity for very low birth weight infants, 1991-1999.
    Pediatrics. 2002 Jul;110(1 Pt 1):143-51 PMID: 12093960
  24. Detection of bacteria in placental tissues obtained from extremely low gestational age neonates.
    Am J Obstet Gynecol. 2008 Jan;198(1):110.e1-7 PMID: 18166321
  25. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops.
    Pediatrics. 1996 Feb;97(2):210-5 PMID: 8584379
  26. Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification.
    Am J Epidemiol. 2008 Nov 1;168(9):980-9 PMID: 18756014
  27. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate.
    J Matern Fetal Neonatal Med. 2008 Jan;21(1):9-23 PMID: 18175241
  28. Outcome of small-for-gestational age and appropriate-for-gestational age infants born before 27 weeks of gestation.
    Pediatrics. 1997 Aug;100(2):E4 PMID: 9233975
  29. Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns.
    Pediatr Dev Pathol. 2004 May-Jun;7(3):237-49 PMID: 15022063
  30. Atypical chronic lung disease in preterm infants.
    J Perinat Med. 2004;32(2):162-7 PMID: 15085893
  31. Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study.
    Pediatrics. 2003 Mar;111(3):483-7 PMID: 12612225
  32. The fetal response to chronic placental insufficiency.
    Semin Perinatol. 2008 Jun;32(3):201-5 PMID: 18482622
  33. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants.
    J Pediatr. 2002 Feb;140(2):171-6 PMID: 11865267
  34. Population-based study of chronic lung disease in very low birth weight infants in North Carolina in 1994 with comparisons with 1984. The North Carolina Neonatologists Association.
    Pediatrics. 1999 Aug;104(2):e17 PMID: 10429135
  35. Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease.
    Am J Respir Crit Care Med. 2007 May 15;175(10):978-85 PMID: 17272782
  36. Effect of in utero growth retardation on lung function at follow-up of prematurely born infants.
    Eur Respir J. 2004 Nov;24(5):731-3 PMID: 15516664
  37. Perinatal factors and the risk of asthma in childhood--a population-based register study in Finland.
    Am J Epidemiol. 2008 Jul 15;168(2):170-8 PMID: 18511427
  38. Intrauterine growth curves based on ultrasonically estimated foetal weights.
    Acta Paediatr. 1996 Jul;85(7):843-8 PMID: 8819552
  39. The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age.
    J Matern Fetal Neonatal Med. 2008 May;21(5):279-87 PMID: 18446652
  40. Hypoxia-induced intrauterine growth retardation: effects on pulmonary development and surfactant protein transcription.
    Biol Neonate. 2005;88(2):129-35 PMID: 15908743
  41. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia.
    Am J Obstet Gynecol. 1999 Oct;181(4):773-9 PMID: 10521727
Article Info
Journal
Pediatrics
Abbr.
Pediatrics
ISSN
1098-4275
DOI
10.1542/peds.2008-3249
Email
[email protected]
Published
2009-09-00
Epub
2009-00-17
Pages
e450-8
Language
English
Region
United States
NLM ID
0376422
PMCID
PMC2891899
Subset
IM
Grants
NINDS NIH HHS · U01 NS040069 · United States
NINDS NIH HHS · U01 NS040069-04 · United States
NINDS NIH HHS · 5U01NS040069-04 · United States
External Links
PubMed source DOI: 10.1542/peds.2008-3249 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2