Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease.

Lancet (London, England) ·Vol. 335 ·No. 8704 ·1990-06-23 ·Pages 1484-7

Geaney DP, Soper N, Shepstone BJ, Cowen PJ

Abstract

Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

MeSH Terms

Aged Alzheimer Disease/diagnostic imaging,physiopathology Analysis of Variance Cerebrovascular Circulation/drug effects,physiology Drug Evaluation Female Glycopyrrolate/administration & dosage,pharmacology Humans Infusions, Intravenous Male Middle Aged Organotechnetium Compounds Oximes Parasympathetic Nervous System/drug effects Parietal Lobe/blood supply Physostigmine/administration & dosage,antagonists & inhibitors,pharmacology Technetium Tc 99m Exametazime Temporal Lobe/blood supply Tomography, Emission-Computed, Single-Photon/methods

Chemicals

Organotechnetium Compounds Oximes Technetium Tc 99m Exametazime Physostigmine Glycopyrrolate

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Geaney D P

University of Oxford, Department of Psychiatry, Warneford Hospital, UK.

Soper N

Shepstone B J

Cowen P J

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/0140-6736(90)93028-n

Published

1990-06-23

Pages

1484-7

Language

English

Region

England

NLM ID

2985213R

Subset

Corrections

CommentIn

PMID: 1974986

External Links

PubMed source DOI: 10.1016/0140-6736(90)93028-n View journal details

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Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease.

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