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PMID: 19729393 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Noninvasive functional and structural connectivity mapping of the human thalamocortical system.

Cerebral cortex (New York, N.Y. : 1991) ·Vol. 20 ·No. 5 ·2010-05-00 ·Pages 1187-94

Zhang D, Snyder AZ, Shimony JS, Fox MD, Raichle ME

Abstract

Relating structural connectivity with functional activity is fundamentally important to understanding the brain's physiology. The thalamocortical system serves as a good model system for exploring structure/function relationships because of its well-documented anatomical connectivity. Here we performed functional and structural magnetic resonance mapping of the human thalamocortical system using intrinsic brain activity and diffusion-weighted imaging. The accuracy of these imaging techniques is tested by comparison with human histology registered to common anatomical space and connectional anatomy derived from nonhuman primates. In general, there is good overall concordance among structural, functional, and histological results which suggests that a simple model of direct anatomical connectivity between the cerebral cortex and the thalamus is capable of explaining much of the observed correlations in neuronal activity. However, important differences between structural and functional mapping results are also manifest which suggests a more complex interpretation and emphasizes the unique contributions from structural and functional mapping.

MeSH Terms
Adult Afferent Pathways/blood supply,metabolism,physiology Brain Mapping Cerebral Cortex/blood supply,metabolism,physiology Diffusion Magnetic Resonance Imaging/methods Female Humans Image Processing, Computer-Assisted/methods Magnetic Resonance Imaging/methods Male Monte Carlo Method Oxygen/blood Rest/physiology Thalamus/blood supply,metabolism,physiology Young Adult
Chemicals
Oxygen
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zhang Dongyang
Department of Radiology, Washington University, St Louis, MO 63110, USA. [email protected]
Snyder Abraham Z
Shimony Joshua S
Fox Michael D
Raichle Marcus E
References (45)
45 references, click to expand
  1. Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior.
    Neuron. 2007 Oct 4;56(1):171-84 PMID: 17920023
  2. Structure and connections of the thalamic reticular nucleus: Advancing views over half a century.
    J Comp Neurol. 2003 Sep 1;463(4):360-71 PMID: 12836172
  3. Combining structural and functional neuroimaging data for studying brain connectivity: a review.
    Psychophysiology. 2008 Mar;45(2):173-87 PMID: 17995910
  4. A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex.
    Neuroimage. 2005 Nov 15;28(3):635-62 PMID: 16172003
  5. Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging.
    Neuroimage. 2004 Apr;21(4):1452-63 PMID: 15050570
  6. Bayesian analysis of neuroimaging data in FSL.
    Neuroimage. 2009 Mar;45(1 Suppl):S173-86 PMID: 19059349
  7. Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus.
    Cereb Cortex. 2005 Jan;15(1):31-9 PMID: 15238447
  8. Predicting human resting-state functional connectivity from structural connectivity.
    Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40 PMID: 19188601
  9. Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain.
    Hum Brain Mapp. 2009 Oct;30(10):3127-41 PMID: 19235882
  10. Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum.
    J Neurosci. 2008 Jun 18;28(25):6453-8 PMID: 18562616
  11. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI.
    Neuroimage. 2006 Jul 15;31(4):1536-48 PMID: 16632379
  12. An investigation of functional and anatomical connectivity using magnetic resonance imaging.
    Neuroimage. 2002 May;16(1):241-50 PMID: 11969331
  13. Tractography gone wild: probabilistic fibre tracking using the wild bootstrap with diffusion tensor MRI.
    IEEE Trans Med Imaging. 2008 Sep;27(9):1268-74 PMID: 18779066
  14. Resting-state functional connectivity reflects structural connectivity in the default mode network.
    Cereb Cortex. 2009 Jan;19(1):72-8 PMID: 18403396
  15. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging.
    Nat Neurosci. 2003 Jul;6(7):750-7 PMID: 12808459
  16. Anatomic localization and quantitative analysis of gradient refocused echo-planar fMRI susceptibility artifacts.
    Neuroimage. 1997 Oct;6(3):156-67 PMID: 9344820
  17. Automated image registration: I. General methods and intrasubject, intramodality validation.
    J Comput Assist Tomogr. 1998 Jan-Feb;22(1):139-52 PMID: 9448779
  18. Registration of [18F]FDG microPET and small-animal MRI.
    Nucl Med Biol. 2005 Aug;32(6):567-72 PMID: 16026703
  19. The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys.
    J Comp Neurol. 1993 Nov 1;337(1):1-31 PMID: 7506270
  20. Mapping the structural core of human cerebral cortex.
    PLoS Biol. 2008 Jul 1;6(7):e159 PMID: 18597554
  21. Intrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function?
    Ann N Y Acad Sci. 2008;1129:119-29 PMID: 18591474
  22. A global optimisation method for robust affine registration of brain images.
    Med Image Anal. 2001 Jun;5(2):143-56 PMID: 11516708
  23. Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study.
    Hum Brain Mapp. 2008 Jun;29(6):671-82 PMID: 17598166
  24. Reliable identification of the auditory thalamus using multi-modal structural analyses.
    Neuroimage. 2006 May 1;30(4):1112-20 PMID: 16473021
  25. An integrated software suite for surface-based analyses of cerebral cortex.
    J Am Med Inform Assoc. 2001 Sep-Oct;8(5):443-59 PMID: 11522765
  26. Intrinsic functional relations between human cerebral cortex and thalamus.
    J Neurophysiol. 2008 Oct;100(4):1740-8 PMID: 18701759
  27. Relative distribution of synapses in the A-laminae of the lateral geniculate nucleus of the cat.
    J Comp Neurol. 2000 Jan 24;416(4):509-20 PMID: 10660881
  28. Characterization and propagation of uncertainty in diffusion-weighted MR imaging.
    Magn Reson Med. 2003 Nov;50(5):1077-88 PMID: 14587019
  29. The human brain is intrinsically organized into dynamic, anticorrelated functional networks.
    Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8 PMID: 15976020
  30. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
    Neuroimage. 2007 Jan 1;34(1):144-55 PMID: 17070705
  31. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
    Magn Reson Med. 1995 Oct;34(4):537-41 PMID: 8524021
  32. Intrinsic functional architecture in the anaesthetized monkey brain.
    Nature. 2007 May 3;447(7140):83-6 PMID: 17476267
  33. Structural and functional analyses of human cerebral cortex using a surface-based atlas.
    J Neurosci. 1997 Sep 15;17(18):7079-102 PMID: 9278543
  34. Advances in functional and structural MR image analysis and implementation as FSL.
    Neuroimage. 2004;23 Suppl 1:S208-19 PMID: 15501092
  35. Cortical network functional connectivity in the descent to sleep.
    Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4489-94 PMID: 19255447
  36. Functional connectivity: integrating behavioral, diffusion tensor imaging, and functional magnetic resonance imaging data sets.
    J Cogn Neurosci. 2005 Apr;17(4):687-93 PMID: 15829087
  37. Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations.
    Neuroimage. 1998 Feb;7(2):119-32 PMID: 9558644
  38. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.
    Nat Rev Neurosci. 2007 Sep;8(9):700-11 PMID: 17704812
  39. Brain work and brain imaging.
    Annu Rev Neurosci. 2006;29:449-76 PMID: 16776593
  40. Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations.
    Neuroimage. 2008 Nov 15;43(3):554-61 PMID: 18771736
  41. The global signal and observed anticorrelated resting state brain networks.
    J Neurophysiol. 2009 Jun;101(6):3270-83 PMID: 19339462
  42. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.
    Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8 PMID: 12506194
  43. Mapping functionally related regions of brain with functional connectivity MR imaging.
    AJNR Am J Neuroradiol. 2000 Oct;21(9):1636-44 PMID: 11039342
  44. Microstructural organization of the cingulum tract and the level of default mode functional connectivity.
    J Neurosci. 2008 Oct 22;28(43):10844-51 PMID: 18945892
  45. Diffusion tensor imaging reveals white matter reorganization in early blind humans.
    Cereb Cortex. 2006 Nov;16(11):1653-61 PMID: 16400157
Article Info
Journal
Cerebral cortex (New York, N.Y. : 1991)
Abbr.
Cereb Cortex
ISSN
1460-2199
DOI
10.1093/cercor/bhp182
Email
[email protected]
Published
2010-05-00
Epub
2009-00-03
Pages
1187-94
Language
English
Region
United States
NLM ID
9110718
PMCID
PMC2852505
Subset
IM
Grants
NIMH NIH HHS · F30MH083483 · United States
NICHD NIH HHS · K23 HD053212 · United States
NINDS NIH HHS · NS06833 · United States
External Links
PubMed source DOI: 10.1093/cercor/bhp182 PMC Full Text View journal details
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