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PMID: 19760240 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations.

European radiology ·Vol. 20 ·No. 3 ·2010-03-00 ·Pages 674-82

Evans MC, Barnes J, Nielsen C, Kim LG, Clegg SL, Blair M, Leung KK, Douiri A, Boyes RG, Ourselin S, Fox NC, Alzheimer's Disease Neuroimaging Initiative

Abstract

To assess the relationship between MRI-derived changes in whole-brain and ventricular volume with change in cognitive scores in Alzheimer's disease (AD), mild cognitive impairment (MCI) and control subjects. In total 131 control, 231 MCI and 99 AD subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with T1-weighted volumetric MRIs from baseline and 12-month follow-up were used to derive volume changes. Mini mental state examination (MMSE), Alzheimer's disease assessment scale (ADAS)-cog and trails test changes were calculated over the same period. Brain atrophy rates and ventricular enlargement differed between subject groups (p < 0.0005) and in MCI and AD were associated with MMSE changes. Both measures were additionally associated with ADAS-cog and trails-B in MCI patients, and ventricular expansion was associated with ADAS-cog in AD patients. Brain atrophy (p < 0.0005) and ventricular expansion rates (p = 0.001) were higher in MCI subjects who progressed to AD within 12 months of follow-up compared with MCI subjects who remained stable. MCI subjects who progressed to AD within 12 months had similar atrophy rates to AD subjects. Whole-brain atrophy rates and ventricular enlargement differed between patient groups and healthy controls, and tracked disease progression and psychological decline, demonstrating their relevance as biomarkers.

MeSH Terms
Aged Alzheimer Disease/complications,pathology Brain/pathology Cognition Disorders/diagnosis,etiology Female Humans Imaging, Three-Dimensional/methods Magnetic Resonance Imaging/methods Male Organ Size Reproducibility of Results Sensitivity and Specificity
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Evans Matthew C
Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Barnes Josephine
Nielsen Casper
Kim Lois G
Clegg Shona L
Blair Melanie
Leung Kelvin K
Douiri Abdel
Boyes Richard G
Ourselin Sebastien
Fox Nick C
Alzheimer's Disease Neuroimaging Initiative
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Article Info
Journal
European radiology
Abbr.
Eur Radiol
ISSN
1432-1084
DOI
10.1007/s00330-009-1581-5
Published
2010-03-00
Epub
2009-00-16
Pages
674-82
Language
English
Region
Germany
NLM ID
9114774
Subset
IM
Grants
Medical Research Council · G0601846 · United Kingdom
Department of Health · United Kingdom
External Links
PubMed source DOI: 10.1007/s00330-009-1581-5 View journal details
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