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PMID: 1979875 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 24 ·1990-12-00 ·Pages 9794-7

Ciccone E, Colonna M, Viale O, Pende D, Di Donato C, Reinharz D, Amoroso A, Jeannet M, Guardiola J, Moretta A

Abstract

The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.

MeSH Terms

Antigens, Differentiation/analysis Antigens, Differentiation, T-Lymphocyte/analysis CD3 Complex CD4 Antigens/analysis Chromosome Mapping Cytotoxicity, Immunologic/genetics Female HLA-B Antigens/genetics Haplotypes Histocompatibility Testing Humans Killer Cells, Natural/immunology Lymphocytes/immunology Major Histocompatibility Complex Male Multigene Family Pedigree Polymorphism, Restriction Fragment Length Receptors, Antigen, T-Cell/analysis Receptors, Fc/analysis Receptors, IgG

Chemicals

Antigens, Differentiation Antigens, Differentiation, T-Lymphocyte CD3 Complex CD4 Antigens HLA-B Antigens Receptors, Antigen, T-Cell Receptors, Fc Receptors, IgG

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Ciccone E

Istituto Nazionale per la Ricerca sul Cancro, Universitá di Genova, Italy.

Colonna M

Viale O

Pende D

Di Donato C

Reinharz D

Amoroso A

Jeannet M

Guardiola J

Moretta A

References (17)

17 references, click to expand

Peculiar immunobiology of bone marrow allografts. II. Rejection of parental grafts by resistant F 1 hybrid mice.
J Exp Med. 1971 Dec 1;134(6):1513-28 PMID: 4942407
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS.
Nature. 1964 Dec 5;204:998-1000 PMID: 14248725
Genetic polymorphism in human glycine-rich beta-glycoprotein.
J Exp Med. 1972 Jan;135(1):68-80 PMID: 4109808
Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide.
Clin Immunol Immunopathol. 1975 Jan;3(3):324-33 PMID: 233982
Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.
J Exp Med. 1983 Aug 1;158(2):571-85 PMID: 6224883
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8699-702 PMID: 3464978
Phenotyping of human complement component C4, a class-III HLA antigen.
Biochem J. 1986 Nov 1;239(3):763-7 PMID: 3103606
Biology and genetics of hybrid resistance.
Adv Immunol. 1987;41:333-445 PMID: 2891262
Bone marrow cell transplants involving intra-H-2 recombinant inbred mouse strains. Evidence that hemopoietic histocompatibility-1 (Hh-1) genes are distinct from H-2D or H-2L.
J Immunol. 1988 Oct 1;141(7):2253-60 PMID: 3049802
Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.
J Exp Med. 1988 Dec 1;168(6):2403-8 PMID: 2974067
A new cluster of genes within the human major histocompatibility complex.
Science. 1989 Jan 13;243(4888):214-7 PMID: 2911734
Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
Proc Natl Acad Sci U S A. 1989 Mar;86(6):1968-72 PMID: 2538825
Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.
EMBO J. 1989 Aug;8(8):2305-12 PMID: 2477242
Specific recognition by CD3- NK cells: a limiting dilution analysis of the frequency of alloreactive CD3- lymphocyte precursors.
Int J Cancer Suppl. 1989;4:56-7 PMID: 2530185
Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8955-8 PMID: 2813433
Biology of natural killer cells.
Adv Immunol. 1989;47:187-376 PMID: 2683611
Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.
J Exp Med. 1990 Jul 1;172(1):47-52 PMID: 1694227

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.87.24.9794

Published

1990-12-00

Pages

9794-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC55260

Subset

Grants

NCI NIH HHS · CA-47554 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1073/pnas.87.24.9794 PMC Full Text View journal details

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Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B.

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