[Receptor caspase-dependent and caspase-independent ways of human lymphocytes apoptosis induced by UV-radiation].

Changes of a structural condition of DNA, expression level of the membrane Fas-receptor and of functional activity of the human lymphocytes caspase-3 in dynamics of apoptosis development, induced by influence of UV-light (240-390 nm) in doses 151, 1510 and 3020 J/m2 are studied. It is established, that the UV-irradiation of lymphocytes in doses of 151 and 1510 J/m2 causes realisation of receptor caspase-dependent apoptosis way. The assumption about switching possibility of receptor caspase-dependent way apoptosis on receptor caspase-independent way at increase of a dose of UV-light to 3020 J/m2 is made.