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PMID: 19809894 Published · ppublish English Journal Article

The matricellular functions of small leucine-rich proteoglycans (SLRPs).

Journal of cell communication and signaling ·Vol. 3 ·No. 3-4 ·2009-12-00 ·Pages 323-35

Merline R, Schaefer RM, Schaefer L

Abstract

The small leucine-rich proteoglycans (SLRPs) are biologically active components of the extracellular matrix (ECM), consisting of a protein core with leucine rich-repeat (LRR) motifs covalently linked to glycosaminoglycan (GAG) side chains. The diversity in composition resulting from the various combinations of protein cores substituted with one or more GAG chains along with their pericellular localization enables SLRPs to interact with a host of different cell surface receptors, cytokines, growth factors, and other ECM components, leading to modulation of cellular functions. SLRPs are capable of binding to: (i) different types of collagens, thereby regulating fibril assembly, organization, and degradation; (ii) Toll-like receptors (TLRs), complement C1q, and tumor necrosis factor-alpha (TNFalpha), regulating innate immunity and inflammation; (iii) epidermal growth factor receptor (EGF-R), insulin-like growth factor receptor (IGF-IR), and c-Met, influencing cellular proliferation, survival, adhesion, migration, tumor growth and metastasis as well as synthesis of other ECM components; (iv) low-density lipoprotein receptor-related protein (LRP-1) and TGF-beta, modulating cytokine activity and fibrogenesis; and (v) growth factors such as bone morphogenic protein (BMP-4) and Wnt-I-induced secreted protein-1 (WISP-1), controlling cell proliferation and differentiation. Thus, the ability of SLRPs, as ECM components, to directly or indirectly regulate cell-matrix crosstalk, resulting in the modulation of various biological processes, aptly qualifies these compounds as matricellular proteins.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Merline Rosetta
Schaefer Roland M
Schaefer Liliana
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Article Info
Journal
Journal of cell communication and signaling
Abbr.
J Cell Commun Signal
ISSN
1873-961X
DOI
10.1007/s12079-009-0066-2
Published
2009-12-00
Epub
2009-00-02
Pages
323-35
Language
English
Region
Netherlands
NLM ID
101308338
PMCID
PMC2778586
External Links
PubMed source DOI: 10.1007/s12079-009-0066-2 PMC Full Text View journal details
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