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PMID: 19812306 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Biogenesis of tail-anchored proteins: the beginning for the end?

Journal of cell science ·Vol. 122 ·No. Pt 20 ·2009-10-15 ·Pages 3605-12

Rabu C, Schmid V, Schwappach B, High S

Abstract

Tail-anchored proteins are a distinct class of integral membrane proteins located in several eukaryotic organelles, where they perform a diverse range of functions. These proteins have in common the C-terminal location of their transmembrane anchor and the resulting post-translational nature of their membrane insertion, which, unlike the co-translational membrane insertion of most other proteins, is not coupled to ongoing protein synthesis. The study of tail-anchored proteins has provided a paradigm for understanding the components and pathways that mediate post-translational biogenesis of membrane proteins at the endoplasmic reticulum. In this Commentary, we review recent studies that have converged at a consensus regarding the molecular mechanisms that underlie this process--namely, that multiple pathways underlie the biogenesis of tail-anchored proteins at the endoplasmic reticulum.

MeSH Terms
Animals Endoplasmic Reticulum/metabolism Golgi Apparatus/metabolism Heat-Shock Proteins/metabolism Humans Membrane Proteins/biosynthesis Protein Transport Signal Recognition Particle/metabolism
Chemicals
Heat-Shock Proteins Membrane Proteins Signal Recognition Particle
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rabu Catherine
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
Schmid Volker
Schwappach Blanche
High Stephen
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Article Info
Journal
Journal of cell science
Abbr.
J Cell Sci
ISSN
1477-9137
DOI
10.1242/jcs.041210
Published
2009-10-15
Pages
3605-12
Language
English
Region
England
NLM ID
0052457
PMCID
PMC2758799
Subset
IM
Grants
Wellcome Trust · 081671 · United Kingdom
Biotechnology and Biological Sciences Research Council · BB/D007879/1 · United Kingdom
External Links
PubMed source DOI: 10.1242/jcs.041210 PMC Full Text View journal details
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