Home LiteratureArticle Details
PMID: 19841095 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation.

Genetics ·Vol. 184 ·No. 1 ·2010-01-00 ·Pages 313-6

Barbash DA

Abstract

Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.

MeSH Terms
Animals Crosses, Genetic Death Dosage Compensation, Genetic/genetics Drosophila melanogaster/classification,genetics,physiology Female Hybridization, Genetic/genetics Male Models, Genetic Mutation Reproducibility of Results X Chromosome/genetics
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Barbash Daniel A
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. [email protected]
References (24)
24 references, click to expand
  1. Pervasive and largely lineage-specific adaptive protein evolution in the dosage compensation complex of Drosophila melanogaster.
    Genetics. 2007 Nov;177(3):1959-62 PMID: 18039888
  2. Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila.
    Science. 2006 Nov 24;314(5803):1292-5 PMID: 17124320
  3. Male-specific lethal mutations of Drosophila melanogaster.
    Genetics. 1980 Sep;96(1):165-86 PMID: 6781985
  4. Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids.
    Genetics. 2006 Nov;174(3):1151-9 PMID: 16951071
  5. Genetic Studies on DROSOPHILA SIMULANS. I. Introduction. Hybrids with DROSOPHILA MELANOGASTER.
    Genetics. 1920 Sep;5(5):488-500 PMID: 17245951
  6. Positive selection at the binding sites of the male-specific lethal complex involved in dosage compensation in Drosophila.
    Genetics. 2008 Oct;180(2):1123-9 PMID: 18780755
  7. A genetic basis for the inviability of hybrids between sibling species of Drosophila.
    Genetics. 1990 Apr;124(4):909-20 PMID: 2108905
  8. Developmental and cell cycle progression defects in Drosophila hybrid males.
    Genetics. 2007 Dec;177(4):2233-41 PMID: 17947412
  9. Chromatin remodeling in dosage compensation.
    Annu Rev Genet. 2005;39:615-51 PMID: 16285873
  10. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription.
    Nat Genet. 2005 Dec;37(12):1361-6 PMID: 16258543
  11. Genetic rescue of inviable hybrids between Drosophila melanogaster and its sibling species.
    Nature. 1987 May 28-Jun 3;327(6120):331-3 PMID: 3108667
  12. Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation.
    J Exp Zool B Mol Dev Evol. 2007 Jan 15;308(1):74-84 PMID: 17075830
  13. Reduced fertility of Drosophila melanogaster hybrid male rescue (Hmr) mutant females is partially complemented by Hmr orthologs from sibling species.
    Genetics. 2009 Apr;181(4):1437-50 PMID: 19153254
  14. The Bristles of Hybrids between DROSOPHILA MELANOGASTER and DROSOPHILA SIMULANS.
    Genetics. 1932 Mar;17(2):153-74 PMID: 17246649
  15. The Drosophila melanogaster hybrid male rescue gene causes inviability in male and female species hybrids.
    Genetics. 2000 Apr;154(4):1747-71 PMID: 10747067
  16. FlyBase: enhancing Drosophila Gene Ontology annotations.
    Nucleic Acids Res. 2009 Jan;37(Database issue):D555-9 PMID: 18948289
  17. Vive la différence: males vs females in flies vs worms.
    Annu Rev Genet. 1996;30:637-702 PMID: 8982468
  18. Species-specific positive selection of the male-specific lethal complex that participates in dosage compensation in Drosophila.
    Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15412-7 PMID: 17878295
  19. Does postzygotic isolation result from improper dosage compensation?
    Genetics. 1989 Aug;122(4):891-4 PMID: 2503427
  20. Drosophila simulans Lethal hybrid rescue mutation (Lhr) rescues inviable hybrids by restoring X chromosomal dosage compensation and causes fluctuating asymmetry of development.
    J Genet. 2007 Dec;86(3):203-15 PMID: 18305340
  21. Loss of the modifiers of variegation Su(var)3-7 or HP1 impacts male X polytene chromosome morphology and dosage compensation.
    J Cell Sci. 2005 Nov 1;118(Pt 21):5047-57 PMID: 16234327
  22. A fine-scale genetic analysis of hybrid incompatibilities in Drosophila.
    Genetics. 2003 Mar;163(3):955-72 PMID: 12663535
  23. SU(VAR)3-7 links heterochromatin and dosage compensation in Drosophila.
    PLoS Genet. 2008 May 02;4(5):e1000066 PMID: 18451980
  24. HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila.
    EMBO J. 2007 Feb 7;26(3):741-51 PMID: 17255947
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
1943-2631
DOI
10.1534/genetics.109.108100
Email
[email protected]
Published
2010-01-00
Epub
2009-00-19
Pages
313-6
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC2815928
Subset
IM
Grants
NIGMS NIH HHS · R01 GM074737 · United States
External Links
PubMed source DOI: 10.1534/genetics.109.108100 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2