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PMID: 19841648 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S. Review

A coming-of-age story: activation-induced cytidine deaminase turns 10.

Nature immunology ·Vol. 10 ·No. 11 ·2009-11-00 ·Pages 1147-53

Delker RK, Fugmann SD, Papavasiliou FN

Abstract

The discovery and characterization of activation-induced cytidine deaminase (AID) 10 years ago provided the basis for a mechanistic understanding of secondary antibody diversification and the subsequent generation and maintenance of cellular memory in B lymphocytes, which signified a major advance in the field of B cell immunology. Here we celebrate and review the triumphs in the mission to understand the mechanisms through which AID influences antibody diversification, as well as the implications of AID function on human physiology. We also take time to point out important ongoing controversies and outstanding questions in the field and highlight key experiments and techniques that hold the potential to elucidate the remaining mysteries surrounding this vital protein.

MeSH Terms
Antibody Diversity B-Lymphocytes/immunology,metabolism Cell Nucleus/genetics,metabolism Cytidine Deaminase/genetics,immunology,metabolism Gene Expression Regulation Protein Processing, Post-Translational RNA Processing, Post-Transcriptional Transcription, Genetic
Chemicals
AICDA (activation-induced cytidine deaminase) Cytidine Deaminase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Delker Rebecca K
Laboratory of Lymphocyte Biology, Rockefeller University, New York, New York, USA.
Fugmann Sebastian D
Papavasiliou F Nina
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.1799
Published
2009-11-00
Epub
2009-00-20
Pages
1147-53
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC2810190
Subset
IM
Grants
NIA NIH HHS · F31 AG034805-01 · United States
NCI NIH HHS · R01 CA098495 · United States
Intramural NIH HHS · United States
NCI NIH HHS · CA098495 · United States
External Links
PubMed source DOI: 10.1038/ni.1799 PMC Full Text View journal details
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