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PMID: 19855405 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Intestinal mucosal barrier function in health and disease.

Nature reviews. Immunology ·Vol. 9 ·No. 11 ·2009-11-00 ·Pages 799-809

Turner JR

Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

MeSH Terms
Animals Cell Membrane Permeability/immunology,physiology Cytokines/immunology,metabolism Cytoskeleton/immunology,metabolism Epithelial Cells/immunology,metabolism Gastrointestinal Tract/immunology,metabolism Homeostasis/immunology,physiology Humans Immunity, Mucosal/immunology Intestinal Diseases/immunology,metabolism Intestinal Mucosa/cytology,immunology,metabolism Membrane Proteins/immunology,metabolism Tight Junctions/immunology,metabolism
Chemicals
Cytokines Membrane Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Turner Jerrold R
Department of Pathology, The University of Chicago, 5841 South Maryland, MC 1089, Chicago, Illinois 60637, USA. [email protected]
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2653
Email
[email protected]
Published
2009-11-00
Pages
799-809
Language
English
Region
England
NLM ID
101124169
Subset
IM
Grants
NIDDK NIH HHS · DK068271 · United States
NIDDK NIH HHS · DK67887 · United States
NIDDK NIH HHS · DK061931 · United States
NIDDK NIH HHS · DK042086 · United States
NCI NIH HHS · CA14599 · United States
NIDDK NIH HHS · R01 DK068271 · United States
NHLBI NIH HHS · HL091889 · United States
External Links
PubMed source DOI: 10.1038/nri2653 View journal details
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