Subcellular distribution of the tumor-specific transplantation antigen of simian virus 40-transformed cells.

Journal of the National Cancer Institute ·Vol. 59 ·No. 4 ·1977-10-00 ·Pages 1291-5

Rogers MJ, Law LW, Appella E

Abstract

TU-5, a simian virus 40 (SV40)-transformed cell line of BALB/c origin, expressed the SV40-specific T-antigen and a transplantation antigen (TSTA). Nuclei and plasma membranes were prepared from these cells and shown on the basis of the distribution of T-antigen and histocompatibility (H-2) antigens to be relatively free of cross contamination. Most of the TSTA, estimated by tumor rejection, was associated with the nuclear fraction.

MeSH Terms

Animals Antigens, Neoplasm Antigens, Viral Cell Fractionation Cell Line Cell Membrane/immunology Cell Nucleus/immunology Cell Transformation, Neoplastic Histocompatibility Antigens Mice Mice, Inbred BALB C Neoplasm Transplantation Simian virus 40/immunology Transplantation, Isogeneic Tumor Virus Infections/immunology

Chemicals

Antigens, Neoplasm Antigens, Viral Histocompatibility Antigens

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Rogers M J

Law L W

Appella E

Article Info

Journal

Journal of the National Cancer Institute

Abbr.

J Natl Cancer Inst

ISSN

0027-8874

DOI

10.1093/jnci/59.4.1291

Published

1977-10-00

Pages

1291-5

Language

English

Region

United States

NLM ID

7503089

Subset

External Links

PubMed source DOI: 10.1093/jnci/59.4.1291 View journal details

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Subcellular distribution of the tumor-specific transplantation antigen of simian virus 40-transformed cells.

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