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PMID: 19866683 Published · ppublish English Journal Article

THE OCCURRENCE AND STRUCTURE OF MICROBODIES : A Comparative Study.

The Journal of cell biology ·Vol. 26 ·No. 3 ·1965-09-01 ·Pages 835-43

Afzelius BA

Abstract

Livers from chickens, rats, mongrel dogs, Dalmatian dogs, and man have been examined in the electron microscope in order to compare the microbodies with the known content of uricase. It is concluded that microbodies with inclusion are present in rats, mongrel dogs, and, although the inclusion generally is smaller, in Dalmatian dogs. The inclusion has a characteristic structural appearance. These species (rat, dog) have uricase. Chickens and man lack both the enzyme uricase and the microbody inclusion. This evidence and that from previously published electron micrographs in the literature on microbodies support the notion of a positive correlation between uricase and microbodies with an inclusion. It is recommended that the term "uricosome" be used for such microbodies that have an inclusion of the appearance here described.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Afzelius B A
Wenner-Gren Institute, University of Stockholm, Stockholm, Sweden.
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.26.3.835
Published
1965-09-01
Pages
835-43
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2106789
External Links
PubMed source DOI: 10.1083/jcb.26.3.835 PMC Full Text View journal details
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