STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE.

The Journal of experimental medicine ·Vol. 117 ·No. 6 ·1963-06-01 ·Pages 1063-74

O'Brien TF, Coons AH

Abstract

Incorporation of 5-bromodeoxyuridine (BUDR) in the culture medium for the 2nd, 3rd, or 4th day after in vitro antigen stimulation of rabbit popliteal lymph node fragments suppressed the in vitro anamnestic antibody response described previously. Before or after this 3-day period, BUDR had no measurable effect. The results suggest that the antibody response in this in vitro system depends upon cell multiplication during this period.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

O'Brien T F

Department of Bacteriology and Immunology, Harvard Medical School, Boston.

Coons A H

References (17)

17 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.117.6.1063

Published

1963-06-01

Pages

1063-74

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137596

External Links

PubMed source DOI: 10.1084/jem.117.6.1063 PMC Full Text View journal details

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STUDIES ON ANTIBODY PRODUCTION : VII. THE EFFECT OF 5-BROMODEOXYURIDINE ON THE IN VITRO ANAMNESTIC ANTIBODY RESPONSE.

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