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PMID: 19869183 Published · ppublish English Journal Article

STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : IV. STREPTOLYSIN.

The Journal of experimental medicine ·Vol. 44 ·No. 2 ·1926-07-31 ·Pages 241-60

Neill JM, Mallory TB

Abstract

The "spontaneous deterioration" of streptolysin has been studied by the methods already used in investigations of the oxidation-reduction of blood pigments and of the lysins of other bacteria. From the results of this study, it may be concluded that the commonly observed "spontaneous deterioration" of streptolysin consists in the conversion of the originally active lysin to a hemolytically inactive oxidation product. This process is a reversible one, and the activity of the lysin is restored by reduction.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Neill J M
Department of Bacteriology and Immunology of Vanderbilt University Medical School, Nashville, and the Department of Bacteriology and Immunology of Harvard University Medical School, Boston.
Mallory T B
References (5)
5 references, click to expand
  1. STUDIES ON OXIDATION AND REDUCTION BY PNEUMOCOCCUS : III. REDUCTION OF METHYLENE BLUE BY STERILE EXTRACTS OF PNEUMOCOCCUS.
    J Exp Med. 1924 Mar 31;39(4):543-52 PMID: 19868864
  2. STUDIES ON THE OXIDATION-REDUCTION OF HEMOGLOBIN AND METHEMOGLOBIN : IV. THE INHIBITION OF "SPONTANEOUS" METHEMOGLOBIN FORMATION.
    J Exp Med. 1925 Mar 31;41(4):561-70 PMID: 19869009
  3. Observations on Hemolysin Production by the Streptococci.
    J Med Res. 1914 Jul;30(3):515-32 PMID: 19972187
  4. STUDIES ON OXIDATION AND REDUCTION BY PNEUMOCOCCUS : V. THE DESTRUCTION OF OXYHEMOGLOBIN BY STERILE EXTRACTS OF PNEUMOCOCCUS.
    J Exp Med. 1924 Apr 30;39(5):757-75 PMID: 19868882
  5. STUDIES ON OXIDATION AND REDUCTION BY PNEUMOCOCCUS : VII. ENZYME ACTIVITY OF STERILE FILTRATES OF AEROBIC AND ANAEROBIC CULTURES OF PNEUMOCOCCUS.
    J Exp Med. 1924 Sep 30;40(4):423-7 PMID: 19868929
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1926-07-31
Pages
241-60
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2131179
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