THE FATE OF VACCINIA VIRUS ON CULTIVATION IN VITRO WITH KUPFFER CELLS (RETICULO-ENDOTHELIAL CELLS).
The pathogenic activity of vaccinia virus is in large part suppressed when it is mixed with living Kupffer cells or clasmatocytes in the test-tube and injected intradermally. Vaccinia increases in quantity when introduced into cultures of Kupffer cells in vitro, and survives in immediate association with these elements. No antiviral principle is elaborated by them under such conditions.
3 references, click to expand
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STUDIES ON THE PRODUCTION OF ANTIBODIES IN VITRO.Science. 1937 Mar 19;85(2203):292-4 PMID: 17787451
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THE CHARACTERS OF KUPFFER CELLS LIVING IN VITRO.J Exp Med. 1934 Apr 30;59(5):593-607 PMID: 19870268
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THE FIXATION AND PROTECTION OF VIRUSES BY THE CELLS OF SUSCEPTIBLE ANIMALS.J Exp Med. 1935 Apr 30;61(5):657-88 PMID: 19870384
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