INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : III. COMPARISON OF ANTIVIRAL SERUM CONSTITUENTS FROM GUINEA PIGS IMMUNIZED WITH ACTIVE OR FORMOLIZED INACTIVE VIRUS.
Earlier experiments had shown that the sera of animals immunized with active virus have much greater protective potency when serum-virus mixtures are injected intraperitoneally into 12 to 15 day old mice than when given intracerebrally. The present work was concerned with similar tests on sera derived from guinea pigs immunized by vaccines in which the virus had been inactivated by formalin. In comparing the content of antiviral body by means of intracerebral and by intraperitoneal inoculation, it was found that both sera show about the same low degree of neutralizing capacity by the former method. By intraperitoneal inoculation, on the other hand, serum collected from guinea pigs immunized by means of active virus reveals high protective power, while that from animals receiving formolized, inactive virus exhibits lower neutralization titers which approach those obtained by the intracerebral method. The significance of this unexpected finding is discussed.
8 references, click to expand
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HUMORAL ANTIBODIES AND RESISTANCE OF VACCINATED AND CONVALESCENT MONKEYS TO POLIOMYELITIS VIRUS.J Exp Med. 1936 Oct 31;64(5):739-48 PMID: 19870565
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INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : II. MECHANISM UNDERLYING THE DIFFERENCE IN PROTECTIVE POWER BY THE TWO ROUTES.J Exp Med. 1938 Oct 31;68(5):761-77 PMID: 19870815
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IMMUNITY OF MICE FOLLOWING SUBCUTANEOUS VACCINATION WITH ST. LOUIS ENCEPHALITIS VIRUS.J Exp Med. 1938 Jun 30;68(1):111-24 PMID: 19870770
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Some Reflections on Virus Immunity: (Section of Comparative Medicine).Proc R Soc Med. 1937 Dec;31(2):59-68 PMID: 19991329
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INTRAPERITONEAL AND INTRACEREBRAL ROUTES IN SERUM PROTECTION TESTS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : I. A COMPARISON OF THE TWO ROUTES IN PROTECTION TESTS.J Exp Med. 1938 Jul 31;68(2):173-89 PMID: 19870781
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ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : III. QUANTITATIVE STUDIES OF SERUM ANTIVIRAL BODIES IN ANIMALS IMMUNIZED WITH ACTIVE AND INACTIVE VIRUS.J Exp Med. 1936 Jul 31;64(2):217-22 PMID: 19870531
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EXPERIMENTS ON ACTIVE IMMUNIZATION AGAINST EXPERIMENTAL POLIOMYELITIS.J Exp Med. 1936 Jan 1;63(1):109-25 PMID: 19870454
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ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS : II. IMMUNIZATION WITH FORMOLIZED VIRUS.J Exp Med. 1936 Apr 30;63(5):745-65 PMID: 19870501
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