A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : I. SEPARATION OF SOLUBLE ANTIGEN FROM VIRUS.
The virus of lymphocytic choriomeningitis can be sedimented in the ultracentrifuge and washed repeatedly; the virus retains its activity provided that a small amount of normal serum is present in the diluent. A soluble substance capable of fixing complement in the presence of immune serum can be separated from the virus. Washed virus fixes complement poorly. The serologically specific soluble antigen is widely distributed in tissues of infected guinea pigs, mice, and monkeys.
7 references, click to expand
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IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS : IV. STATISTICAL STUDIES OF ELEMENTARY BODIES IN RELATION TO INFECTION AND AGGLUTINATION.J Exp Med. 1936 Aug 31;64(3):439-52 PMID: 19870546
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MENINGITIS IN MAN CAUSED BY A FILTERABLE VIRUS : II. IDENTIFICATION OF THE ETIOLOGICAL AGENT.J Exp Med. 1936 Feb 29;63(3):415-32 PMID: 19870480
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A HIGH SPEED VACUUM CENTRIFUGE SUITABLE FOR THE STUDY OF FILTERABLE VIRUSES.J Exp Med. 1936 Sep 30;64(4):503-28 PMID: 19870550
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IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : III. ANTIGENICITY AND PATHOGENICITY OF EXTRACTS OF THE GROWTHS OF WILD AND DOMESTIC SPECIES: GENERAL DISCUSSION.J Exp Med. 1938 Oct 31;68(5):737-59 PMID: 19870814
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INFECTIOUS MYXOMATOSIS OF RABBITS : PREPARATION OF ELEMENTARY BODIES AND STUDIES OF SEROLOGICALLY ACTIVE MATERIALS ASSOCIATED WITH THE DISEASE.J Exp Med. 1937 Jun 30;66(1):1-14 PMID: 19870643
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THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI.J Exp Med. 1939 Mar 31;69(4):517-32 PMID: 19870861
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ELEMENTARY BODIES OF VACCINIA FROM INFECTED CHORIO-ALLANTOIC MEMBRANES OF DEVELOPING CHICK EMBRYOS.J Exp Med. 1937 Aug 31;66(3):325-36 PMID: 19870666
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