THE ROENTGEN RADIATION OF PAPILLOMA VIRUS (SHOPE) : II. THE EFFECT OF X-RAYS UPON PAPILLOMA VIRUS IN VITRO.

The Journal of experimental medicine ·Vol. 74 ·No. 3 ·1941-08-31 ·Pages 223-34

Syverton JT, Berry GP, Warren SL

Abstract

Cell-free suspensions of papilloma virus (Shope) required for their inactivation in vitro amounts of Roentgen irradiation that are much greater than those needed to inactivate other infectious agents previously described. These amounts, millions of r units, are several thousand times greater than those required to eradicate permanently papillomas induced by the virus in domestic rabbits. Large doses of Roentgen radiation reduce the titer of papilloma virus, lengthen the period of time between inoculation and the appearance of papillomas, and decrease the size attained by the papillomas.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Syverton J T

Departments of Bacteriology and Medicine (Radiology), University of Rochester, School of Medicine and Dentistry, Rochester, New York.

Berry G P

Warren S L

References (9)

9 references, click to expand

IMMUNIZATION OF RABBITS TO INFECTIOUS PAPILLOMATOSIS.
J Exp Med. 1937 Jan 31;65(2):219-31 PMID: 19870596
SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : II. TESTS OF THE BLOOD OF ANIMALS CARRYING VARIOUS EPITHELIAL TUMORS.
J Exp Med. 1936 Jun 30;64(1):79-96 PMID: 19870525
THE MASKING EFFECT OF EXTRAVASATED ANTIBODY ON THE RABBIT PAPILLOMA VIRUS (SHOPE).
J Exp Med. 1939 Nov 30;70(6):583-604 PMID: 19870932
INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY.
J Exp Med. 1933 Oct 31;58(5):607-24 PMID: 19870219
SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : I. TESTS OF THE BLOOD OF ANIMALS CARRYING THE PAPILLOMA.
J Exp Med. 1936 Jun 30;64(1):63-77 PMID: 19870523
OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM : I. THE INFLUENCE OF THE HOST SPECIES AND OF THE PATHOGENIC ACTIVITY AND CONCENTRATION OF THE VIRUS.
J Exp Med. 1936 Aug 31;64(3):385-400 PMID: 19870543
THE ROENTGEN RADIATION OF PAPILLOMA VIRUS (SHOPE) : I. THE EFFECT OF X-RAYS UPON PAPILLOMAS ON DOMESTIC RABBITS.
J Exp Med. 1941 Jan 31;73(2):243-8 PMID: 19871075
THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE).
J Exp Med. 1935 Sep 30;62(4):523-48 PMID: 19870432
CANCERS DERIVING FROM THE VIRUS PAPILLOMAS OF WILD RABBITS UNDER NATURAL CONDITIONS.
J Exp Med. 1940 Mar 31;71(4):469-94 PMID: 19870976

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.74.3.223

Published

1941-08-31

Pages

223-34

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2135178

External Links

PubMed source DOI: 10.1084/jem.74.3.223 PMC Full Text View journal details

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THE ROENTGEN RADIATION OF PAPILLOMA VIRUS (SHOPE) : II. THE EFFECT OF X-RAYS UPON PAPILLOMA VIRUS IN VITRO.

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