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PMID: 19871183 Published · ppublish English Journal Article

QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : IV. ADDITION OF HUMAN COMPLEMENT TO SPECIFIC PRECIPITATES.

The Journal of experimental medicine ·Vol. 75 ·No. 3 ·1942-03-01 ·Pages 285-95

Heidelberger M, Mayer M

Abstract

1. A modified method is given for the titration of human complement so that C'1 titers are measured, as in guinea pig serum, instead of the C'2 titers yielded by the usual titration. 2. The measurement of complement combining component or components in weight units, instead of relative terms, is carried out as in guinea pig serum and leads to similar values, 0.03 to 0.05 mg. of C' N per ml. of human serum. 3. Other similarities in human and guinea pig complements are noted and discussed.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Heidelberger M
Departments of Medicine and Biochemistry, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.
Mayer M
References (7)
7 references, click to expand
  1. A FURTHER STUDY OF THE CROSS REACTION BETWEEN THE SPECIFIC POLYSACCHARIDES OF TYPES III AND VIII PNEUMOCOCCI IN HORSE ANTISERA.
    J Exp Med. 1942 Jan 1;75(1):35-47 PMID: 19871166
  2. THE PREPARATION AND PHYSICOCHEMICAL CHARACTERIZATION OF THE SERUM PROTEIN COMPONENTS OF COMPLEMENT.
    J Exp Med. 1941 Sep 30;74(4):297-308 PMID: 19871136
  3. QUANTITATIVE STUDIES ON THE PRECIPITIN REACTION : ANTIBODY PRODUCTION IN RABBITS INJECTED WITH AN AZO PROTEIN.
    J Exp Med. 1933 Jul 31;58(2):137-52 PMID: 19870185
  4. QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : III. UPTAKE OF COMPLEMENT NITROGEN UNDER VARYING EXPERIMENTAL CONDITIONS.
    J Exp Med. 1941 Sep 30;74(4):359-67 PMID: 19871140
  5. QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS.
    J Exp Med. 1941 May 31;73(6):695-709 PMID: 19871106
  6. QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : I. A METHOD.
    J Exp Med. 1941 May 31;73(6):681-94 PMID: 19871105
  7. A QUANTITATIVE THEORY OF THE PRECIPITIN REACTION : III. THE REACTION BETWEEN CRYSTALLINE EGG ALBUMIN AND ITS HOMOLOGOUS ANTIBODY.
    J Exp Med. 1935 Oct 31;62(5):697-720 PMID: 19870443
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1942-03-01
Pages
285-95
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2135246
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