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PMID: 19871434 Published · ppublish English Journal Article

THE SEDIMENTATION RATE OF THE BIOLOGICAL ACTIVITIES OF INFLUENZA A VIRUS.

The Journal of experimental medicine ·Vol. 80 ·No. 6 ·1944-12-01 ·Pages 521-9

Lauffer MA, Miller GL

Abstract

The sedimentation rates of the mouse infectivity principles of the PR8 and the F12 strains of influenza A virus were shown by studies in the separation cell to have values which are not significantly different from sedimentation rates of the principal components of purified preparations. It was shown further that the bulk of the chicken red blood cell agglutinating activity and of the chick embryo infectivity of PR8 influenza virus preparations sediments at the same rate as that of the 100 mmicro. component. Some activity was shown to be associated with aggregates. These results lend strong support to the assumption that the three biological activities are associated with the particles characterized as spheres with a diameter of about 100 mmicro.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lauffer M A
Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey.
Miller G L
References (12)
12 references, click to expand
  1. ELECTROPHORETIC STUDIES ON PR8 INFLUENZA VIRUS.
    J Exp Med. 1944 Dec 1;80(6):549-59 PMID: 19871436
  2. A STUDY OF CONDITIONS FOR THE OPTIMUM PRODUCTION OF PR8 INFLUENZA VIRUS IN CHICK EMBRYOS.
    J Exp Med. 1944 Feb 1;79(2):173-83 PMID: 19871361
  3. THE MOUSE INFECTIVITY TITRATION OF INFLUENZA VIRUS.
    J Exp Med. 1944 Feb 1;79(2):197-203 PMID: 19871363
  4. TITRATION OF INFLUENZA VIRUS IN CHICK EMBRYOS.
    J Exp Med. 1944 May 1;79(5):487-95 PMID: 19871383
  5. STUDIES ON THE NATURE OF THE VIRUS OF INFLUENZA : II. THE SIZE OF THE INFECTIOUS UNIT IN INFLUENZA A.
    J Exp Med. 1943 Mar 1;77(3):265-76 PMID: 19871281
  6. ISOLATION AND CHARACTERIZATION OF INFLUENZA VIRUS B (LEE STRAIN).
    Science. 1943 Oct 1;98(2544):307-8 PMID: 17776068
  7. THE SIZE OF INFLUENZA VIRUS.
    J Exp Med. 1944 Mar 1;79(3):267-83 PMID: 19871369
  8. QUANTITATIVE ASPECTS OF THE RED BLOOD CELL AGGLUTINATION TEST FOR INFLUENZA VIRUS.
    J Exp Med. 1944 Feb 1;79(2):185-95 PMID: 19871362
  9. THE AGGLUTINATION OF RED CELLS BY ALLANTOIC FLUID OF CHICK EMBRYOS INFECTED WITH INFLUENZA VIRUS.
    Science. 1941 Jul 4;94(2427):22-3 PMID: 17777315
  10. BIOPHYSICAL PROPERTIES OF PREPARATIONS OF PR8 INFLUENZA VIRUS.
    J Exp Med. 1944 Dec 1;80(6):531-48 PMID: 19871435
  11. CENTRIFUGATION AND ULTRAFILTRATION STUDIES ON ALLANTOIC FLUID PREPARATIONS OF INFLUENZA VIRUS.
    J Exp Med. 1944 Mar 1;79(3):301-17 PMID: 19871372
  12. AN IMPROVED AIR-DRIVEN TYPE OF ULTRACENTRIFUGE FOR MOLECULAR SEDIMENTATION.
    J Exp Med. 1937 Mar 31;65(4):565-86 PMID: 19870619
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1944-12-01
Pages
521-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2135489
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