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PMID: 19871610 Published · ppublish English Journal Article

ANTIBODY FORMATION IN MEN FOLLOWING INJECTION OF FOUR TYPE-SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS.

The Journal of experimental medicine ·Vol. 85 ·No. 3 ·1947-02-28 ·Pages 227-30

Heidelberger M, Macleod CM, Hodges RG, Bernhard WG, di Lapi MM

Abstract

1. Random selections of the sera of trainees injected 2 months previously with the specific polysaccharides of Types I, II, V, and VII pneumococci contained quantities of antibody to Types I, II, and VII sufficient to account for the favorable results of the immunization procedure. 2. As in earlier studies, the levels of the antibody for the C polysaccharide remained relatively constant before and after the injections. 3. The serum from the preliminary bleedings often contained antibody to the Type VII polysaccharide. This remained relatively constant in a control group injected with saline.

Keywords
ANTIGENS AND ANTIBODIES PNEUMOCOCCI/immunity SACCHARIDES/poly-
MeSH Terms
Antibodies Antibody Formation Antigens Humans Immunity Immunization Immunoglobulins Male Polysaccharides Polysaccharides, Bacterial Streptococcus pneumoniae
Chemicals
Antibodies Antigens Immunoglobulins Polysaccharides Polysaccharides, Bacterial
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Heidelberger M
Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls.
Macleod C M
Hodges R G
Bernhard W G
di Lapi M M
References (2)
2 references, click to expand
  1. QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS.
    Science. 1943 Apr 30;97(2522):405-6 PMID: 17832515
  2. PREVENTION OF PNEUMOCOCCAL PNEUMONIA BY IMMUNIZATION WITH SPECIFIC CAPSULAR POLYSACCHARIDES.
    J Exp Med. 1945 Nov 30;82(6):445-65 PMID: 19871511
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1947-02-28
Pages
227-30
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2135695
Subset
OM
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