Mst out and HCC in.

Cancer cell ·Vol. 16 ·No. 5 ·2009-11-06 ·Pages 363-4

Zhao B, Lei Q, Guan KL

Abstract

Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.

MeSH Terms

Animals Liver Neoplasms, Experimental/enzymology,genetics Mice Mice, Knockout Protein Serine-Threonine Kinases/deficiency,genetics Serine-Threonine Kinase 3

Chemicals

Stk4 protein, mouse Protein Serine-Threonine Kinases Serine-Threonine Kinase 3 Stk3 protein, mouse

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Zhao Bin

Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA.

Lei Qunying

Guan Kun-Liang

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1878-3686

DOI

10.1016/j.ccr.2009.10.008

Published

2009-11-06

Pages

363-4

Language

English

Region

United States

NLM ID

101130617

Subset

Corrections

CommentOn

PMID: 19878874

External Links

PubMed source DOI: 10.1016/j.ccr.2009.10.008 View journal details

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