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PMID: 19901143 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations.

Archives of internal medicine ·Vol. 169 ·No. 20 ·2009-11-09 ·Pages 1897-906

Corella D, Peloso G, Arnett DK, Demissie S, Cupples LA, Tucker K, Lai CQ, Parnell LD, Coltell O, Lee YC, Ordovas JM

Abstract

Nutrigenetics studies the role of genetic variation on interactions between diet and health, aiming to provide more personalized dietary advice. However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level. Cross-sectional, follow-up (20 years), and case-control analyses were undertaken in 3 independent populations. We analyzed gene-diet interactions between the APOA2 -265T>C polymorphism and saturated fat intake on BMI and obesity in 3462 individuals from 3 populations in the United States: the Framingham Offspring Study (1454 whites), the Genetics of Lipid Lowering Drugs and Diet Network Study (1078 whites), and Boston-Puerto Rican Centers on Population Health and Health Disparities Study (930 Hispanics of Caribbean origin). Prevalence of the CC genotype in study participants ranged from 10.5% to 16.2%. We identified statistically significant interactions between the APOA2 -265T>C and saturated fat regarding BMI in all 3 populations. Thus, the magnitude of the difference in BMI between the individuals with the CC and TT+TC genotypes differed by saturated fat. A mean increase in BMI of 6.2% (range, 4.3%-7.9%; P = .01) was observed between genotypes with high- (> or =22 g/d) but not with low- saturated fat intake in all studies. Likewise, the CC genotype was significantly associated with higher obesity prevalence in all populations only in the high-saturated fat stratum. Meta-analysis estimations of obesity for individuals with the CC genotype compared with the TT+TC genotype were an odds ratio of 1.84 (95% confidence interval, 1.38-2.47; P < .001) in the high-saturated fat stratum, but no association was detected in the low-saturated fat stratum (odds ratio, 0.81; 95% confidence interval, 0.59-1.11; P = .18). For the first time to our knowledge, a gene-diet interaction influencing BMI and obesity has been strongly and consistently replicated in 3 independent populations.

MeSH Terms
Adult Aged Aged, 80 and over Apolipoprotein A-II/genetics Body Composition/genetics Body Mass Index Case-Control Studies Confidence Intervals Cross-Sectional Studies Dietary Fats/adverse effects Eating/genetics Ethnicity/genetics Female Follow-Up Studies Gene Expression Regulation Genetic Predisposition to Disease Genotype Humans Logistic Models Male Middle Aged Multivariate Analysis Nutritional Status/genetics Obesity/diet therapy,ethnology,genetics Odds Ratio Polymorphism, Genetic Probability Risk Assessment Whites/genetics
Chemicals
Apolipoprotein A-II Dietary Fats
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Corella Dolores
Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111-1524, USA.
Peloso Gina
Arnett Donna K
Demissie Serkalem
Cupples L Adrienne
Tucker Katherine
Lai Chao-Qiang
Parnell Laurence D
Coltell Oscar
Lee Yu-Chi
Ordovas Jose M
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Article Info
Journal
Archives of internal medicine
Abbr.
Arch Intern Med
ISSN
1538-3679
DOI
10.1001/archinternmed.2009.343
Published
2009-11-09
Pages
1897-906
Language
English
Region
United States
NLM ID
0372440
PMCID
PMC2874956
Subset
IM
Grants
NIA NIH HHS · P01 AG023394 · United States
NHLBI NIH HHS · HL-54776 · United States
NHLBI NIH HHS · U01 HL072524 · United States
NHLBI NIH HHS · R01 HL054776-12 · United States
NHLBI NIH HHS · U01 HL072524-06 · United States
NHLBI NIH HHS · R01 HL054776 · United States
NIA NIH HHS · 5P01AG023394-05 · United States
NHLBI NIH HHS · U 01 HL72524 · United States
NIA NIH HHS · P01 AG023394-05 · United States
NIDDK NIH HHS · DK075030 · United States
External Links
PubMed source DOI: 10.1001/archinternmed.2009.343 PMC Full Text
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