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PMID: 19904280 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Understanding microRNAs in neurodegeneration.

Nature reviews. Neuroscience ·Vol. 10 ·No. 12 ·2009-12-00 ·Pages 837-41

Eacker SM, Dawson TM, Dawson VL

Abstract

Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

MeSH Terms
Animals Brain Chemistry/genetics,physiology Cell Survival/physiology Humans MicroRNAs/genetics,physiology Nerve Degeneration/genetics,physiopathology Nerve Tissue Proteins/metabolism Neurons/physiology
Chemicals
MicroRNAs Nerve Tissue Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Eacker Stephen M
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. [email protected]
Dawson Ted M
Dawson Valina L
References (43)
43 references, click to expand
  1. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.
    Nat Neurosci. 2008 Oct;11(10):1137-9 PMID: 18758459
  2. Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons.
    J Neurochem. 2003 Feb;84(4):803-13 PMID: 12562524
  3. The granulin gene family: from cancer to dementia.
    Bioessays. 2009 Nov;31(11):1245-54 PMID: 19795409
  4. A brain-specific microRNA regulates dendritic spine development.
    Nature. 2006 Jan 19;439(7074):283-9 PMID: 16421561
  5. APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.
    Brain. 2006 Nov;129(Pt 11):2977-83 PMID: 16921174
  6. Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration.
    Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5614-9 PMID: 18385371
  7. APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.
    Hum Mutat. 2009 Aug;30(8):1207-13 PMID: 19462468
  8. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.
    Hum Mol Genet. 2008 Dec 1;17(23):3631-42 PMID: 18723524
  9. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.
    Am J Hum Genet. 2008 Feb;82(2):283-9 PMID: 18252210
  10. The impact of microRNAs on protein output.
    Nature. 2008 Sep 4;455(7209):64-71 PMID: 18668037
  11. The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development.
    Genes Dev. 2007 Apr 1;21(7):744-9 PMID: 17403776
  12. MicroRNA pathways modulate polyglutamine-induced neurodegeneration.
    Mol Cell. 2006 Oct 6;24(1):157-63 PMID: 17018300
  13. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.
    EMBO J. 2009 Mar 18;28(6):697-710 PMID: 19197241
  14. miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex.
    Development. 2008 Dec;135(23):3911-21 PMID: 18997113
  15. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.
    J Neurosci. 2008 Dec 31;28(53):14341-6 PMID: 19118166
  16. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus.
    J Neurosci. 2008 Apr 23;28(17):4322-30 PMID: 18434510
  17. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.
    Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16426-31 PMID: 16260724
  18. A microRNA-based gene dysregulation pathway in Huntington's disease.
    Neurobiol Dis. 2008 Mar;29(3):438-45 PMID: 18082412
  19. Biogenesis of small RNAs in animals.
    Nat Rev Mol Cell Biol. 2009 Feb;10(2):126-39 PMID: 19165215
  20. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.
    Nat Cell Biol. 2009 Jun;11(6):705-16 PMID: 19465924
  21. Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
    Am J Hum Genet. 2006 Jun;78(6):936-46 PMID: 16685645
  22. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.
    Nature. 2009 Jul 23;460(7254):479-86 PMID: 19536157
  23. Cerebellar neurodegeneration in the absence of microRNAs.
    J Exp Med. 2007 Jul 9;204(7):1553-8 PMID: 17606634
  24. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
    Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9 PMID: 15451224
  25. Cell-cycle control of microRNA-mediated translation regulation.
    Cell Cycle. 2008 Jun 1;7(11):1545-9 PMID: 18469529
  26. FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.
    Mov Disord. 2009 Feb 15;24(3):455-9 PMID: 19133659
  27. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers.
    Br J Pharmacol. 2009 May;157(2):166-78 PMID: 19459843
  28. Reciprocal actions of REST and a microRNA promote neuronal identity.
    Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7 PMID: 16461918
  29. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche.
    Nat Neurosci. 2009 Apr;12(4):399-408 PMID: 19287386
  30. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.
    Annu Rev Pathol. 2006;1:151-70 PMID: 18039111
  31. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
    Hum Mol Genet. 2006 Oct 15;15(20):2988-3001 PMID: 16950801
  32. Widespread changes in protein synthesis induced by microRNAs.
    Nature. 2008 Sep 4;455(7209):58-63 PMID: 18668040
  33. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
    Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20 PMID: 18434550
  34. A MicroRNA feedback circuit in midbrain dopamine neurons.
    Science. 2007 Aug 31;317(5842):1220-4 PMID: 17761882
  35. Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.
    Brain. 2006 Nov;129(Pt 11):2984-91 PMID: 16931535
  36. Members of the miRNA-200 family regulate olfactory neurogenesis.
    Neuron. 2008 Jan 10;57(1):41-55 PMID: 18184563
  37. MicroRNAs: target recognition and regulatory functions.
    Cell. 2009 Jan 23;136(2):215-33 PMID: 19167326
  38. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    Nat Rev Genet. 2008 Feb;9(2):102-14 PMID: 18197166
  39. miRNA in situ hybridization in formaldehyde and EDC-fixed tissues.
    Nat Methods. 2009 Feb;6(2):139-41 PMID: 19137005
  40. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
    Nature. 2006 Aug 24;442(7105):916-9 PMID: 16862116
  41. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
    Nat Genet. 2006 Jan;38(1):24-6 PMID: 16369530
  42. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
    Nature. 2006 Aug 24;442(7105):920-4 PMID: 16862115
  43. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
    Nat Genet. 2003 Sep;35(1):76-83 PMID: 12881722
Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn2726
Email
[email protected]
Published
2009-12-00
Epub
2009-00-11
Pages
837-41
Language
English
Region
England
NLM ID
100962781
PMCID
PMC4120241
Subset
IM
Grants
NIDA NIH HHS · P50 DA000266 · United States
NINDS NIH HHS · P50 NS038377 · United States
NIDA NIH HHS · DA00266 · United States
External Links
PubMed source DOI: 10.1038/nrn2726 PMC Full Text View journal details
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