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PMID: 19917845 Published · ppublish English Clinical Trial Journal Article Multicenter Study Research Support, N.I.H., Extramural

Immunochemotherapy and autologous stem-cell transplantation for untreated patients with mantle-cell lymphoma: CALGB 59909.

Damon LE, Johnson JL, Niedzwiecki D, Cheson BD, Hurd DD, Bartlett NL, Lacasce AS, Blum KA, Byrd JC, Kelly M, Stock W, Linker CA, Canellos GP

Abstract

PURPOSE Mantle-cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma with a poor prognosis. We explored the feasibility, safety, and effectiveness of an aggressive immunochemotherapy treatment program that included autologous stem-cell transplantation (ASCT) for patients up to age 69 years with newly diagnosed MCL. PATIENTS AND METHODS The primary end point was 2-year progression-free survival (PFS). A successful trial would yield a 2-year PFS of at least 50% and an event rate (early progression plus nonrelapse mortality) less than 20% at day +100 following ASCT. Seventy-eight patients were treated with two or three cycles of rituximab combined with methotrexate and augmented CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). This treatment was followed by intensification with high doses of cytarabine and etoposide combined with rituximab and filgrastim to mobilize autologous peripheral-blood stem cells. Patients then received high doses of carmustine, etoposide, and cyclophosphamide followed by ASCT and two doses of rituximab. Results There were two nonrelapse mortalities, neither during ASCT. With a median follow-up of 4.7 years, the 2-year PFS was 76% (95% CI, 64% to 85%), and the 5-year PFS was 56% (95% CI, 43% to 68%). The 5-year overall survival was 64% (95% CI, 50% to 75%). The event rate by day +100 of ASCT was 5.1%. CONCLUSION The Cancer and Leukemia Group B 59909 regimen is feasible, safe, and effective in patients with newly diagnosed MCL. The incorporation of rituximab with aggressive chemotherapy and ASCT may be responsible for the encouraging outcomes demonstrated in this study, which produced results comparable to similar treatment regimens.

MeSH Terms
Adult Aged Antibodies, Monoclonal/therapeutic use Antibodies, Monoclonal, Murine-Derived Antineoplastic Combined Chemotherapy Protocols/administration & dosage,therapeutic use Combined Modality Therapy Cyclophosphamide/administration & dosage Cytarabine/administration & dosage Disease-Free Survival Doxorubicin/administration & dosage Etoposide/administration & dosage Female Filgrastim Granulocyte Colony-Stimulating Factor/administration & dosage Hematopoietic Stem Cell Transplantation Humans Immunologic Factors/therapeutic use Immunotherapy/methods Lymphoma, Mantle-Cell/drug therapy,genetics,surgery,therapy Male Middle Aged Prednisone/administration & dosage Recombinant Proteins Rituximab Survival Rate Transplantation Conditioning Vincristine/administration & dosage
Chemicals
Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Immunologic Factors Recombinant Proteins Cytarabine Granulocyte Colony-Stimulating Factor Rituximab Vincristine Etoposide Doxorubicin Cyclophosphamide Filgrastim Prednisone
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Damon Lloyd E
University of California Medical Center, The Helen Diller Comprehensive Cancer Center, 400 Parnassus Ave, San Francisco, CA 94143-0324, USA. [email protected]
Johnson Jeffrey L
Niedzwiecki Donna
Cheson Bruce D
Hurd David D
Bartlett Nancy L
Lacasce Ann S
Blum Kristie A
Byrd John C
Kelly Michael
Stock Wendy
Linker Charles A
Canellos George P
Supplementary Concepts
CHOP protocol (Protocol)
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Article Info
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Abbr.
J Clin Oncol
ISSN
1527-7755
Published
2009-12-20
Epub
2009-00-16
Pages
6101-8
Language
English
Region
United States
NLM ID
8309333
PMCID
PMC2793032
Subset
IM
Grants
NCI NIH HHS · U10 CA032291 · United States
NCI NIH HHS · CA32291 · United States
NCI NIH HHS · CA41287 · United States
NCI NIH HHS · U10 CA033601 · United States
NCI NIH HHS · U10 CA077597 · United States
NCI NIH HHS · U10 CA077440 · United States
NCI NIH HHS · CA77440 · United States
NCI NIH HHS · U10 CA041287 · United States
NCI NIH HHS · CA77658 · United States
NCI NIH HHS · CA33601 · United States
NCI NIH HHS · CA77597 · United States
NCI NIH HHS · CA11789 · United States
NCI NIH HHS · U10 CA077658 · United States
NCI NIH HHS · CA03927 · United States
NCI NIH HHS · U10 CA031946 · United States
NCI NIH HHS · CA31946 · United States
NCI NIH HHS · U10 CA003927 · United States
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