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PMID: 19930621 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The nature of cell-cycle checkpoints: facts and fallacies.

Journal of biology ·Vol. 8 ·No. 10 ·2009-00-00 ·Pages 88

Khodjakov A, Rieder CL

Abstract

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.

MeSH Terms
Cell Cycle/physiology Genes, cdc/physiology Models, Biological
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Khodjakov Alexey
Wadsworth Center, Albany, NY 12201-0509, USA. [email protected]
Rieder Conly L
References (11)
11 references, click to expand
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Article Info
Journal
Journal of biology
Abbr.
J Biol
ISSN
1475-4924
DOI
10.1186/jbiol195
Email
[email protected]
Published
2009-00-00
Pages
88
Language
English
Region
England
NLM ID
101147570
PMCID
PMC2790835
Subset
IM
Grants
NIGMS NIH HHS · R01 GM059363 · United States
NIGMS NIH HHS · R01 GM059363-11 · United States
NIGMS NIH HHS · R37 GM040198 · United States
NIGMS NIH HHS · R37 GM040198-25 · United States
NIGMS NIH HHS · GM 40198 · United States
NIGMS NIH HHS · GM 59363 · United States
External Links
PubMed source DOI: 10.1186/jbiol195 PMC Full Text
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