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PMID: 19935802 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Naive T cell homeostasis: from awareness of space to a sense of place.

Nature reviews. Immunology ·Vol. 9 ·No. 12 ·2009-12-00 ·Pages 823-32

Takada K, Jameson SC

Abstract

The peripheral naive T cell pool is fairly stable in number, diversity and functional competence in the absence of vigorous immune responses. However, this apparent tranquility is not an intrinsic property of T cells but involves continuous tuning of the T cell pool composition by homeostatic signals. In the past decade, studies have revealed that naive T cells rely on combinatorial signals from self-peptide-MHC complexes and interleukin-7 for their physical and functional maintenance. Competition for these factors dictates T cell 'space'. In addition, recent studies show that these and other homeostatic factors are offered to T cells on stromal cell networks, which also serve to guide T cell trafficking in secondary lymphoid organs. Such findings suggest the importance of 'place' in the perception and integration of homeostatic cues for the maintenance and functional tuning of the naive T cell pool.

MeSH Terms
Animals Chemotaxis, Leukocyte/immunology Homeostasis/immunology Humans T-Lymphocytes/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Takada Kensuke
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Jameson Stephen C
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2657
Published
2009-12-00
Pages
823-32
Language
English
Region
England
NLM ID
101124169
Subset
IM
Grants
NIAID NIH HHS · R37 AI038903 · United States
External Links
PubMed source DOI: 10.1038/nri2657 View journal details
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