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PMID: 20007900 Published · ppublish English Historical Article Journal Article Research Support, Non-U.S. Gov't

Mapping human genetic diversity in Asia.

Science (New York, N.Y.) ·Vol. 326 ·No. 5959 ·2009-12-11 ·Pages 1541-5

HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen CH, Chen J, Chen YT, Chu J, Cutiongco-de la Paz EM, De Ungria MC, Delfin FC, Edo J, Fuchareon S, Ghang H, Gojobori T, Han J, Ho SF, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana P, Kim HL, Kim K, Kim S, Kim WY, Kimm K, Kimura R, Koike T, Kulawonganunchai S, Kumar V, Lai PS, Lee JY, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu JY, Xiao H, Xu S, Yang JO, Shugart YY, Yoo HS, Yuan W, Zhao G, Zilfalil BA, Indian Genome Variation Consortium

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

MeSH Terms
Algorithms Asia Asians/genetics,history Bayes Theorem Cluster Analysis Emigration and Immigration/history Ethnicity/genetics,history Gene Flow Genotype Geography Haplotypes History, Ancient Humans Language Linguistics Oligonucleotide Array Sequence Analysis Phylogeny Polymorphism, Single Nucleotide Principal Component Analysis
Authors & Affiliations
94 authors, click to expand affiliations / ORCID
HUGO Pan-Asian SNP Consortium
Abdulla Mahmood Ameen
Ahmed Ikhlak
Assawamakin Anunchai
Bhak Jong
Brahmachari Samir K
Calacal Gayvelline C
Chaurasia Amit
Chen Chien-Hsiun
Chen Jieming
Chen Yuan-Tsong
Chu Jiayou
Cutiongco-de la Paz Eva Maria C
De Ungria Maria Corazon A
Delfin Frederick C
Edo Juli
Fuchareon Suthat
Ghang Ho
Gojobori Takashi
Han Junsong
Ho Sheng-Feng
Hoh Boon Peng
Huang Wei
Inoko Hidetoshi
Jha Pankaj
Jinam Timothy A
Jin Li
Jung Jongsun
Kangwanpong Daoroong
Kampuansai Jatupol
Kennedy Giulia C
Khurana Preeti
Kim Hyung-Lae
Kim Kwangjoong
Kim Sangsoo
Kim Woo-Yeon
Kimm Kuchan
Kimura Ryosuke
Koike Tomohiro
Kulawonganunchai Supasak
Kumar Vikrant
Lai Poh San
Lee Jong-Young
Lee Sunghoon
Liu Edison T
Majumder Partha P
Mandapati Kiran Kumar
Marzuki Sangkot
Mitchell Wayne
Mukerji Mitali
Naritomi Kenji
Ngamphiw Chumpol
Niikawa Norio
Nishida Nao
Oh Bermseok
Oh Sangho
Ohashi Jun
Oka Akira
Ong Rick
Padilla Carmencita D
Palittapongarnpim Prasit
Perdigon Henry B
Phipps Maude Elvira
Png Eileen
Sakaki Yoshiyuki
Salvador Jazelyn M
Sandraling Yuliana
Scaria Vinod
Seielstad Mark
Sidek Mohd Ros
Sinha Amit
Srikummool Metawee
Sudoyo Herawati
Sugano Sumio
Suryadi Helena
Suzuki Yoshiyuki
Tabbada Kristina A
Tan Adrian
Tokunaga Katsushi
Tongsima Sissades
Villamor Lilian P
Wang Eric
Wang Ying
Wang Haifeng
Wu Jer-Yuarn
Xiao Huasheng
Xu Shuhua
Yang Jin Ok
Shugart Yin Yao
Yoo Hyang-Sook
Yuan Wentao
Zhao Guoping
Zilfalil Bin Alwi
Indian Genome Variation Consortium
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2009-12-11
Pages
1541-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Corrections
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