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PMID: 2002556 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Minimal Rev-response element for type 1 human immunodeficiency virus.

Journal of virology ·Vol. 65 ·No. 4 ·1991-04-00 ·Pages 2131-4

Huang XJ, Hope TJ, Bond BL, McDonald D, Grahl K, Parslow TG

Abstract

Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.

MeSH Terms
Base Sequence Binding Sites Genes, env HIV-1/genetics Molecular Sequence Data Mutation Nucleic Acid Conformation RNA, Messenger/chemistry Repetitive Sequences, Nucleic Acid
Chemicals
RNA, Messenger
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Huang X J
Department of Pathology, University of California, San Francisco 94143-0506.
Hope T J
Bond B L
McDonald D
Grahl K
Parslow T G
References (16)
16 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.4.2131-2134.1991
Published
1991-04-00
Pages
2131-4
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC240087
Subset
IM
Grants
NIAID NIH HHS · AI29313 · United States
Databases
GENBANK
M59809, M59810, M61066, M61067, M61068, M61069, M61070, M61071, M64439, M64492
External Links
PubMed source DOI: 10.1128/JVI.65.4.2131-2134.1991 PMC Full Text View journal details
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