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PMID: 20029446 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Post-transcriptional regulons coordinate the initiation and resolution of inflammation.

Nature reviews. Immunology ·Vol. 10 ·No. 1 ·2010-01-00 ·Pages 24-35

Anderson P

Abstract

Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.

MeSH Terms
Animals Gene Expression Regulation/immunology Humans Inflammation/genetics,immunology Protein Biosynthesis/genetics,immunology RNA, Messenger/biosynthesis,genetics,immunology Regulon/genetics,immunology Transcription, Genetic/genetics,immunology
Chemicals
RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Anderson Paul
Department of Medicine, Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. [email protected]
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri2685
Email
[email protected]
Published
2010-01-00
Pages
24-35
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri2685 View journal details
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