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PMID: 20060699 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The inflammasomes: mechanisms of activation and function.

Current opinion in immunology ·Vol. 22 ·No. 1 ·2010-02-00 ·Pages 28-33

Latz E

Abstract

In response to injurious or infectious agents caspase-1 activating multiprotein complexes, termed inflammasomes, assemble in the cytoplasm of cells. Activated caspase-1 cleaves the proforms of the interleukin-1 cytokine family members leading to their activation and secretion. The IL-1 family cytokines have multiple proinflammatory activities implicating them in the pathogenesis of many inflammatory diseases. While defined ligands have been identified for the NLRP1, IPAF, and AIM2 inflammasomes, little is known about the activation mechanisms of the NLRP3 inflammasome. Numerous different molecular entities, such as various crystals, pore-forming toxins, or extracellular ATP can trigger the NLRP3 inflammasome. Recent work proposes that NLRP3 is activated indirectly by host factors that are generated in response to NLRP3 triggers.

MeSH Terms
Animals Caspase 1/metabolism Humans Inflammation/immunology,metabolism Intercellular Signaling Peptides and Proteins/metabolism Interleukin-1beta/immunology Protein Binding Signal Transduction
Chemicals
Intercellular Signaling Peptides and Proteins Interleukin-1beta Caspase 1
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Latz Eicke
University of Massachusetts Medical School, Department of Infectious Diseases and Immunology, 364 Plantation St, Worcester, MA 01605, USA. [email protected]
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
1879-0372
DOI
10.1016/j.coi.2009.12.004
Email
[email protected]
Published
2010-02-00
Epub
2010-00-08
Pages
28-33
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2844336
Subset
IM
Grants
NIAID NIH HHS · R01 AI083713 · United States
NHLBI NIH HHS · R01 HL093262-01A1 · United States
NHLBI NIH HHS · R01 HL093262 · United States
NIAID NIH HHS · AI-065483 · United States
NIAID NIH HHS · R01 AI065483 · United States
NIAID NIH HHS · AI-083713 · United States
NIAID NIH HHS · R01 AI083713-01 · United States
External Links
PubMed source DOI: 10.1016/j.coi.2009.12.004 PMC Full Text View journal details
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