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PMID: 20066075 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow.

Cold Spring Harbor perspectives in biology ·Vol. 1 ·No. 1 ·2009-07-00 ·Pages a000802

Hirokawa N, Tanaka Y, Okada Y

Abstract

Mammalian left-right determination is a good example for how multiple cell biological processes coordinate in the formation of a basic body plan. The leftward movement of fluid at the ventral node, called nodal flow, is the central process in symmetry breaking on the left-right axis. Nodal flow is autonomously generated by the rotation of posteriorly tilted cilia that are built by transport via KIF3 motor on cells of the ventral node. How nodal flow is interpreted to create left-right asymmetry has been a matter of debate. Recent evidence suggests that the leftward movement of sheathed lipidic particles, called nodal vesicular parcels (NVPs), may result in the activation of the noncanonical hedgehog signaling pathway, an asymmetric elevation in intracellular Ca(2+) and changes in gene expression.

MeSH Terms
Animals Biology/methods Body Patterning Cilia/metabolism Embryo, Mammalian/metabolism Humans Kinesins/metabolism Mice Models, Biological Signal Transduction
Chemicals
KIF3A protein, human Kinesins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hirokawa Nobutaka
Department of Cell Biology and Anatomy, University of Tokyo, Graduate School of Medicine, 7-3-1 Hongo, Tokyo, 113-0033 Japan. [email protected]
Tanaka Yosuke
Okada Yasushi
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a000802
Email
[email protected]
Published
2009-07-00
Pages
a000802
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC2742083
Subset
IM
External Links
PubMed source DOI: 10.1101/cshperspect.a000802 PMC Full Text View journal details
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