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PMID: 20083110 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Molecular mechanism and physiological role of pexophagy.

FEBS letters ·Vol. 584 ·No. 7 ·2010-04-02 ·Pages 1367-73

Manjithaya R, Nazarko TY, Farré JC, Subramani S

Abstract

Pexophagy is a selective autophagy process wherein damaged and/or superfluous peroxisomes undergo vacuolar degradation. In methylotropic yeasts, where pexophagy has been studied most extensively, this process occurs by either micro- or macropexophagy: processes analogous to micro- and macroautophagy. Recent studies have identified specific factors and illustrated mechanisms involved in pexophagy. Although mechanistically pexophagy relies heavily on the core autophagic machinery, the latest findings about the role of auxiliary pexophagy factors have highlighted specialized membrane structures required for micropexophagy, and shown how cargo selectivity is achieved and how cargo size dictates the requirement for these factors during pexophagy. These insights and additional observations in the literature provide a framework for an understanding of the physiological role(s) of pexophagy.

MeSH Terms
Autophagy/physiology Cytoskeleton/metabolism Peroxisomes/metabolism Phagosomes/metabolism Phosphatidylinositols/metabolism Saccharomyces cerevisiae/cytology,metabolism
Chemicals
Phosphatidylinositols
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Manjithaya Ravi
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0322, USA.
Nazarko Taras Y
Farré Jean-Claude
Subramani Suresh
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Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
1873-3468
Published
2010-04-02
Epub
2010-00-17
Pages
1367-73
Language
English
Region
England
NLM ID
0155157
PMCID
PMC2843806
Subset
IM
Grants
NIGMS NIH HHS · R01 GM069373 · United States
NIGMS NIH HHS · R01 GM069373-04 · United States
NIGMS NIH HHS · GM069373 · United States
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