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PMID: 200835 Published · ppublish English Journal Article

Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway.

Molecular & general genetics : MGG ·Vol. 154 ·No. 3 ·1977-09-09 ·Pages 269-77

Karst F, Lacroute F

Abstract

Thermosensitive mutants, auxotrophic for ergosterol synthesis, have been isolated, analyzed genetically and their enzymatic deficiencies investigated. These mutants were classified into seven unlinked complementation groups. These groupes lack the following enzymatic activities: squalene epoxidase (erg 1), 2,3-oxidosqualene-lanosterol cyclase (erg 7), phosphomevalonic kinase (erg 8), mevalonic kinase (erg12) and squalene synthetase (erg 9, erg 10, erg 11).

MeSH Terms
Epoxy Compounds Ergosterol/biosynthesis Farnesyl-Diphosphate Farnesyltransferase/metabolism Hot Temperature Intramolecular Transferases Isomerases/metabolism Lanosterol Mevalonic Acid/metabolism Mutation Oxygenases/metabolism Phosphotransferases/metabolism Saccharomyces cerevisiae/enzymology,genetics,isolation & purification Squalene/metabolism
Chemicals
Epoxy Compounds Lanosterol Squalene Oxygenases Farnesyl-Diphosphate Farnesyltransferase Phosphotransferases Isomerases Intramolecular Transferases lanosterol synthase Mevalonic Acid Ergosterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Karst F
Lacroute F
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26 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00571282
Published
1977-09-09
Pages
269-77
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00571282
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