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PMID: 20090858 Published · ppublish English Journal Article

Molecular Imaging of Myocardial Injury: A Magnetofluorescent Approach.

Current cardiovascular imaging reports ·Vol. 2 ·No. 1 ·2009-02-01 ·Pages 33-39

Sosnovik DE

Abstract

The role of molecular imaging in enhancing the understanding of myocardial injury and repair is rapidly expanding. Moreover, in recent years magnetic resonance and fluorescence-based approaches have been added to the molecular imaging armamentarium and have been used to image selected molecular and cellular targets in the myocardium. Apoptosis, necrosis, macrophage infiltration, myeloperoxidase activity, cathepsin activity, and type 1 collagen have all been imaged in vivo with a magnetofluorescent (MRI and/or fluorescence) approach. This review highlights the potential of these and other magnetofluorescent agents, with particular focus on their role in ischemic heart disease.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sosnovik David E
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
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Article Info
Journal
Current cardiovascular imaging reports
Abbr.
Curr Cardiovasc Imaging Rep
ISSN
1941-9066
DOI
10.1007/s12410-009-0005-x
Published
2009-02-01
Pages
33-39
Language
English
Region
United States
NLM ID
101484775
PMCID
PMC2808047
Grants
NHLBI NIH HHS · K08 HL079984 · United States
NHLBI NIH HHS · R01 HL093038-01 · United States
NHLBI NIH HHS · R01 HL093038-02 · United States
NHLBI NIH HHS · R01 HL093038 · United States
NHLBI NIH HHS · K08 HL079984-05 · United States
External Links
PubMed source DOI: 10.1007/s12410-009-0005-x PMC Full Text View journal details
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