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PMID: 20093003 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators.

Current opinion in genetics & development ·Vol. 20 ·No. 1 ·2010-02-00 ·Pages 41-50

Huang L, Muthuswamy SK

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.

MeSH Terms
Adaptor Proteins, Signal Transducing Animals Apoptosis Carcinoma/genetics,metabolism Cell Cycle Proteins/metabolism Cell Movement Cell Polarity/genetics Cell Proliferation Eye Proteins/metabolism Gene Expression Humans Membrane Proteins/genetics,metabolism Neoplasms/genetics,metabolism Nerve Tissue Proteins/metabolism Nucleoside-Phosphate Kinase/metabolism
Chemicals
Adaptor Proteins, Signal Transducing CRB1 protein, human Cell Cycle Proteins Eye Proteins Membrane Proteins Nerve Tissue Proteins PARD3 protein, human Nucleoside-Phosphate Kinase MPP5 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huang Ling
Ontario Cancer Institute, Campbell Family Institute for Breast Cancer Research, Dept. of Medical Biophysics, University of Toronto, Toronto, Canada.
Muthuswamy Senthil K
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Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
1879-0380
DOI
10.1016/j.gde.2009.12.001
Published
2010-02-00
Epub
2010-00-21
Pages
41-50
Language
English
Region
England
NLM ID
9111375
PMCID
PMC3015045
Subset
IM
Grants
NCI NIH HHS · R01 CA098830 · United States
NCI NIH HHS · R56 CA098830 · United States
NCI NIH HHS · R56 CA098830-05A1 · United States
NCI NIH HHS · CA098830 · United States
External Links
PubMed source DOI: 10.1016/j.gde.2009.12.001 PMC Full Text View journal details
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