Home LiteratureArticle Details
PMID: 20133832 Published · ppublish English Comment Journal Article

An in vivo demonstration of functional G protein-coupled receptor dimers.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 107 ·No. 5 ·2010-02-02 ·Pages 1819-20

Vassart G

Abstract

暂无摘要

MeSH Terms
Amino Acid Substitution Animals Fertility/genetics,physiology Genetic Complementation Test Infertility, Male/genetics,physiopathology Male Mice Mutation Protein Multimerization Protein Structure, Quaternary Receptors, G-Protein-Coupled/chemistry,physiology Receptors, LH/chemistry,deficiency,genetics,physiology Sequence Deletion
Chemicals
Receptors, G-Protein-Coupled Receptors, LH
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Vassart Gilbert
Faculty of Medicine, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Free University of Brussels, 808 route Lennik, B-1070 Brussels, Belgium. [email protected]
References (20)
20 references, click to expand
  1. Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
    Mol Endocrinol. 2002 Apr;16(4):736-46 PMID: 11923470
  2. The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.
    J Biol Chem. 2003 Feb 14;278(7):4385-8 PMID: 12496294
  3. Asymmetric conformational changes in a GPCR dimer controlled by G-proteins.
    EMBO J. 2006 Dec 13;25(24):5693-702 PMID: 17139258
  4. Dopamine D2 receptors form higher order oligomers at physiological expression levels.
    EMBO J. 2008 Sep 3;27(17):2293-304 PMID: 18668123
  5. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
    Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9050-5 PMID: 15932946
  6. Contribution of negative cooperativity to the thyrotropin-receptor interaction in normal human thyroid: kinetic evaluation.
    Proc Natl Acad Sci U S A. 1979 Feb;76(2):705-9 PMID: 218217
  7. Target size of the adenosine Ri receptor.
    Biochem J. 1986 Apr 15;235(2):621-4 PMID: 3017310
  8. Structure of human follicle-stimulating hormone in complex with its receptor.
    Nature. 2005 Jan 20;433(7023):269-77 PMID: 15662415
  9. Atomic-force microscopy: Rhodopsin dimers in native disc membranes.
    Nature. 2003 Jan 9;421(6919):127-8 PMID: 12520290
  10. Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice.
    Endocrinology. 2004 Mar;145(3):1453-63 PMID: 14645113
  11. Allosteric properties of G protein-coupled receptor oligomers.
    Pharmacol Ther. 2007 Sep;115(3):410-8 PMID: 17655934
  12. Heterodimerization of g protein-coupled receptors: specificity and functional significance.
    Pharmacol Rev. 2005 Sep;57(3):289-98 PMID: 16109836
  13. The apparent cooperativity of some GPCRs does not necessarily imply dimerization.
    Trends Pharmacol Sci. 2009 Apr;30(4):182-7 PMID: 19269046
  14. Oligomerization of G-protein-coupled transmitter receptors.
    Nat Rev Neurosci. 2001 Apr;2(4):274-86 PMID: 11283750
  15. A molecular dissection of the glycoprotein hormone receptors.
    Trends Biochem Sci. 2004 Mar;29(3):119-26 PMID: 15003269
  16. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.
    Nat Chem Biol. 2009 Sep;5(9):688-95 PMID: 19648932
  17. Two defective heterozygous luteinizing hormone receptors can rescue hormone action.
    J Biol Chem. 2002 May 3;277(18):15795-800 PMID: 11859079
  18. Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit.
    Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10859-64 PMID: 17578920
  19. Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.
    Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2319-24 PMID: 20080658
  20. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
    Proc Natl Acad Sci U S A. 2007 May 1;104(18):7682-7 PMID: 17452637
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.0914432107
Email
[email protected]
Published
2010-02-02
Epub
2010-00-01
Pages
1819-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2836705
Subset
IM
Corrections
CommentOn
PMID: 20080658
External Links
PubMed source DOI: 10.1073/pnas.0914432107 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2