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PMID: 20154681 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The peroxisomal importomer constitutes a large and highly dynamic pore.

Nature cell biology ·Vol. 12 ·No. 3 ·2010-03-00 ·Pages 273-7

Meinecke M, Cizmowski C, Schliebs W, Krüger V, Beck S, Wagner R, Erdmann R

Abstract

The peroxisomal protein import machinery differs fundamentally from known translocons (endoplasmic reticulum, mitochondria, chloroplasts, bacteria) as it allows membrane passage of folded, even oligomerized proteins. However, the mechanistic principles of protein translocation across the peroxisomal membrane remain unknown. There are various models that consider membrane invagination events, vesicle fusion or the existence of large import pores. Current data show that a proteinaceous peroxisomal importomer enables docking of the cytosolic cargo-loaded receptors, cargo translocation and receptor recycling. Remarkably, the cycling import receptor Pex5p changes its topology from a soluble cytosolic form to an integral membrane-bound form. According to the transient pore hypothesis, the membrane-bound receptor is proposed to form the core component of the peroxisomal import pore. Here, we demonstrate that the membrane-associated import receptor Pex5p together with its docking partner Pex14p forms a gated ion-conducting channel which can be opened to a diameter of about 9 nm by the cytosolic receptor-cargo complex. The newly identified pore shows striking dynamics, as expected for an import machinery translocating proteins of variable sizes.

MeSH Terms
Acyl-CoA Oxidase/metabolism Carrier Proteins/genetics Electrophysiological Phenomena/physiology Gene Deletion Ion Channel Gating/physiology Ion Channels/physiology Membrane Potentials/physiology Membrane Proteins/analysis,physiology Membrane Transport Proteins/analysis,physiology Membranes, Artificial Models, Biological Multiprotein Complexes/chemistry,isolation & purification,physiology Peroxins Peroxisome-Targeting Signal 1 Receptor Peroxisomes/physiology Porins/analysis,physiology Protein Transport/physiology Receptors, Cytoplasmic and Nuclear/analysis,physiology Repressor Proteins/analysis,physiology Saccharomyces cerevisiae/chemistry,physiology Saccharomyces cerevisiae Proteins/analysis,genetics,metabolism,physiology Ubiquitin-Protein Ligases/analysis,physiology Unilamellar Liposomes/chemistry
Chemicals
Carrier Proteins Ion Channels Membrane Proteins Membrane Transport Proteins Membranes, Artificial Multiprotein Complexes PEX10 protein, S cerevisiae PEX12 protein, S cerevisiae PEX13 protein, S cerevisiae PEX14 protein, S cerevisiae PEX17 protein, S cerevisiae PEX18 protein, S cerevisiae PEX21 protein, S cerevisiae PEX5 protein, S cerevisiae Peroxins Peroxisome-Targeting Signal 1 Receptor Pex8 protein, S cerevisiae Porins Receptors, Cytoplasmic and Nuclear Repressor Proteins Saccharomyces cerevisiae Proteins Unilamellar Liposomes Acyl-CoA Oxidase POX1 protein, S cerevisiae Ubiquitin-Protein Ligases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Meinecke Michael
Biophysik, FB Biologie/Chemie, Universität Osnabrück, Germany.
Cizmowski Christian
Schliebs Wolfgang
Krüger Vivien
Beck Sabrina
Wagner Richard
Erdmann Ralf
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1476-4679
Published
2010-03-00
Epub
2010-00-14
Pages
273-7
Language
English
Region
England
NLM ID
100890575
Subset
IM
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