1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists.

Acrylates/chemical synthesis,chemistry,pharmacology Angiotensin II/antagonists & inhibitors,metabolism Angiotensin Receptor Antagonists Animals Aorta/drug effects,physiology Blood Pressure/drug effects Dogs Imidazoles/chemical synthesis,chemistry,pharmacology In Vitro Techniques Indicators and Reagents Kidney/drug effects,physiology Molecular Conformation Molecular Structure Muscle, Smooth, Vascular/drug effects,physiology Rabbits Rats Receptors, Angiotensin/drug effects,metabolism Structure-Activity Relationship Thiophenes Vasoconstriction/drug effects

Acrylates Angiotensin Receptor Antagonists Imidazoles Indicators and Reagents Receptors, Angiotensin Thiophenes Angiotensin II eprosartan