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PMID: 20197050 Published · ppublish English Journal Article

New uses for old drugs: neonatal diabetes and sulphonylureas.

Cell metabolism ·Vol. 11 ·No. 3 ·2010-03-03 ·Pages 179-81

Ashcroft FM

Abstract

The discovery that their neonatal diabetes is caused by gain-of-function mutations in the K(ATP) channel has enabled many patients to switch from insulin to oral sulphonylurea drugs. Here, I review molecular, physiological, and clinical features of this change in therapy.

MeSH Terms
Animals Diabetes Mellitus/congenital,drug therapy,genetics,physiopathology Diabetes Mellitus, Experimental/drug therapy,physiopathology Humans Infant, Newborn Insulin/metabolism,therapeutic use KATP Channels/genetics,metabolism Mice Mutation Sulfonylurea Compounds/therapeutic use
Chemicals
Insulin KATP Channels Sulfonylurea Compounds
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ashcroft Frances M
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, UK. [email protected]
Article Info
Journal
Cell metabolism
Abbr.
Cell Metab
ISSN
1932-7420
DOI
10.1016/j.cmet.2010.02.004
Email
[email protected]
Published
2010-03-03
Pages
179-81
Language
English
Region
United States
NLM ID
101233170
Subset
IM
External Links
PubMed source DOI: 10.1016/j.cmet.2010.02.004 View journal details
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