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PMID: 20201015 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Critical functions of priming and lysosomal damage for NLRP3 activation.

European journal of immunology ·Vol. 40 ·No. 3 ·2010-03-00 ·Pages 620-3

Hornung V, Latz E

Abstract

Inflammasomes are cytosolic multi-protein complexes that form in response to infectious or injurious challenges. Inflammasomes control the activity of caspase-1, which is essential for the maturation and release of IL-1beta family cytokines. The NLRP1, IPAF and AIM2 inflammasomes recognize specific substances, while the NLRP3 inflammasome responds to many structurally and chemically diverse triggers. Here, we discuss the critical roles of priming and lysosomal damage in NLRP3 inflammasome activation.

MeSH Terms
Animals Carrier Proteins/immunology Humans Inflammation/immunology Lysosomes/immunology Multiprotein Complexes/immunology NLR Family, Pyrin Domain-Containing 3 Protein
Chemicals
Carrier Proteins Multiprotein Complexes NLR Family, Pyrin Domain-Containing 3 Protein NLRP3 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hornung Veit
Institute for Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany.
Latz Eicke
References (22)
22 references, click to expand
  1. Plant pathogens and integrated defence responses to infection.
    Nature. 2001 Jun 14;411(6839):826-33 PMID: 11459065
  2. Signaling by ROS drives inflammasome activation.
    Eur J Immunol. 2010 Mar;40(3):616-9 PMID: 20201014
  3. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
    J Immunol. 2003 Dec 15;171(12):6329-33 PMID: 14662828
  4. Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis.
    J Immunol. 2005 Dec 1;175(11):7611-22 PMID: 16301671
  5. Pathogen recognition and innate immunity.
    Cell. 2006 Feb 24;124(4):783-801 PMID: 16497588
  6. Host-microbe interactions: shaping the evolution of the plant immune response.
    Cell. 2006 Feb 24;124(4):803-14 PMID: 16497589
  7. Cryopyrin activates the inflammasome in response to toxins and ATP.
    Nature. 2006 Mar 9;440(7081):228-32 PMID: 16407890
  8. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
    Immunity. 2007 Apr;26(4):433-43 PMID: 17433728
  9. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
    Science. 2008 May 2;320(5876):674-7 PMID: 18403674
  10. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
    Nat Immunol. 2008 Aug;9(8):857-65 PMID: 18604209
  11. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.
    Nat Immunol. 2008 Aug;9(8):866-72 PMID: 18604212
  12. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
    Nat Immunol. 2008 Aug;9(8):847-56 PMID: 18604214
  13. Initial description of the human NLRP3 promoter.
    Genes Immun. 2008 Dec;9(8):721-6 PMID: 18719602
  14. Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
    Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5 PMID: 19139407
  15. The inflammasomes: guardians of the body.
    Annu Rev Immunol. 2009;27:229-65 PMID: 19302040
  16. Immunological and inflammatory functions of the interleukin-1 family.
    Annu Rev Immunol. 2009;27:519-50 PMID: 19302047
  17. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*).
    Annu Rev Immunol. 2009;27:621-68 PMID: 19302049
  18. AIMing 2 detect foreign DNA.
    Sci Signal. 2009;2(77):pe39 PMID: 19567913
  19. Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation.
    J Immunol. 2009 Jul 15;183(2):792-6 PMID: 19542372
  20. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
    J Immunol. 2009 Jul 15;183(2):787-91 PMID: 19570822
  21. Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
    PLoS One. 2009;4(8):e6510 PMID: 19652710
  22. Toll-like receptors.
    Annu Rev Immunol. 2003;21:335-76 PMID: 12524386
Article Info
Journal
European journal of immunology
Abbr.
Eur J Immunol
ISSN
1521-4141
DOI
10.1002/eji.200940185
Published
2010-03-00
Pages
620-3
Language
English
Region
Germany
NLM ID
1273201
PMCID
PMC3893565
Subset
IM
Grants
NIAID NIH HHS · R01 AI083713 · United States
NIAID NIH HHS · AI-065483 · United States
NIAID NIH HHS · R01 AI065483 · United States
NIAID NIH HHS · AI-083713 · United States
European Research Council · 243046 · International
External Links
PubMed source DOI: 10.1002/eji.200940185 PMC Full Text View journal details
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