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PMID: 20202120 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Review: autophagy and neurodegeneration: survival at a cost?

Neuropathology and applied neurobiology ·Vol. 36 ·No. 2 ·2010-04-00 ·Pages 125-32

Cherra SJ, Dagda RK, Chu CT

Abstract

Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway for the degradation of long-lived proteins, effete organelles and protein aggregates. Aberrations in macroautophagy have been observed in Alzheimer, Huntington, Parkinson, motor neuron and prion diseases. In this review, we will discuss the divergent roles of macroautophagy in neurodegenerative diseases and suggest a potential regulatory mechanism that could determine cell death or survival outcomes. We also highlight emerging data on neurite morphology and synaptic remodelling that indicate the possibility of detrimental functional trade-offs in the face of neuronal cell survival, particularly if the need for elevated macroautophagy is sustained.

MeSH Terms
Animals Autophagy/physiology Cell Survival/physiology Humans Models, Neurological Neurodegenerative Diseases/physiopathology Neurons/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cherra S J
Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop St., Rm. W958 BST, Pittsburgh, PA 15261, USA.
Dagda R K
Chu C T
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Article Info
Journal
Neuropathology and applied neurobiology
Abbr.
Neuropathol Appl Neurobiol
ISSN
1365-2990
DOI
10.1111/j.1365-2990.2010.01062.x
Published
2010-04-00
Epub
2010-00-19
Pages
125-32
Language
English
Region
England
NLM ID
7609829
PMCID
PMC2860012
Subset
IM
Grants
NIA NIH HHS · R01 AG026389-03 · United States
NINDS NIH HHS · F31 NS064728 · United States
NIA NIH HHS · AG026389 · United States
NINDS NIH HHS · F31 NS064728-01 · United States
NIA NIH HHS · R01 AG026389 · United States
NIA NIH HHS · R01 AG026389-03S1 · United States
External Links
PubMed source DOI: 10.1111/j.1365-2990.2010.01062.x PMC Full Text View journal details
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