PRDM9 points the zinc finger at meiotic recombination hotspots.

Genome biology ·Vol. 11 ·No. 2 ·2010-00-00 ·Pages 104

Neale MJ

Abstract

Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.

MeSH Terms

Animals Chromatin/genetics DNA Breaks, Double-Stranded Evolution, Molecular Founder Effect Histone Methyltransferases Histone-Lysine N-Methyltransferase/genetics Humans Meiosis/genetics Mice Pan troglodytes/genetics Recombination, Genetic Saccharomyces cerevisiae/genetics Zinc Fingers/genetics

Chemicals

Chromatin Histone Methyltransferases Histone-Lysine N-Methyltransferase PRDM9 protein, human

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Neale Matthew J

MRC Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. [email protected]

References (11)

11 references, click to expand

Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites.
EMBO J. 2009 Jan 21;28(2):99-111 PMID: 19078966
Where the crossovers are: recombination distributions in mammals.
Nat Rev Genet. 2004 Jun;5(6):413-24 PMID: 15153994
A fine-scale map of recombination rates and hotspots across the human genome.
Science. 2005 Oct 14;310(5746):321-4 PMID: 16224025
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase.
Nature. 2005 Nov 17;438(7066):374-8 PMID: 16292313
Probing meiotic recombination decisions.
Dev Cell. 2008 Sep;15(3):331-2 PMID: 18804427
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
Science. 2010 Feb 12;327(5967):876-9 PMID: 20044541
A common sequence motif associated with recombination hot spots and genome instability in humans.
Nat Genet. 2008 Sep;40(9):1124-9 PMID: 19165926
Distinct histone modifications define initiation and repair of meiotic recombination in the mouse.
EMBO J. 2009 Sep 2;28(17):2616-24 PMID: 19644444
Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.
PLoS Genet. 2009 Dec;5(12):e1000753 PMID: 19997497
Prdm9 controls activation of mammalian recombination hotspots.
Science. 2010 Feb 12;327(5967):835 PMID: 20044538
PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.
Science. 2010 Feb 12;327(5967):836-40 PMID: 20044539

Article Info

Journal

Genome biology

Abbr.

Genome Biol

ISSN

1474-760X

DOI

10.1186/gb-2010-11-2-104

[email protected]

Published

2010-00-00

Epub

2010-00-26

Pages

104

Language

English

Region

England

NLM ID

100960660

PMCID

PMC2872867

Subset

Corrections

CommentOn

PMID: 20044539

External Links

PubMed source DOI: 10.1186/gb-2010-11-2-104 PMC Full Text View journal details

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PRDM9 points the zinc finger at meiotic recombination hotspots.

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