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PMID: 20227034 Published · ppublish English Comment Journal Article

IDH1 and IDH2: not your typical oncogenes.

Cancer cell ·Vol. 17 ·No. 3 ·2010-03-16 ·Pages 215-6

Reitman ZJ, Parsons DW, Yan H

Abstract

Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Reitman Zachary J
The Preston Robert Tisch Brain Tumor Center at Duke, The Pediatric Brain Tumor Institute, and The Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Parsons D Williams
Yan Hai
References (10)
10 references, click to expand
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Article Info
Journal
Cancer cell
Abbr.
Cancer Cell
ISSN
1878-3686
DOI
10.1016/j.ccr.2010.02.024
Published
2010-03-16
Pages
215-6
Language
English
Region
United States
NLM ID
101130617
PMCID
PMC4467912
Grants
NCI NIH HHS · R01 CA140316 · United States
Corrections
CommentOn
PMID: 20171147
External Links
PubMed source DOI: 10.1016/j.ccr.2010.02.024 PMC Full Text View journal details
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